Astragaloside IV reduces neuronal apoptosis and parthanatos in ischemic injury by preserving mitochondrial hexokinase-II
Y Li, Y Yang, Y Zhao, J Zhang, B Liu, S Jiao… - Free Radical Biology and …, 2019 - Elsevier
Cerebral ischemia induces neuronal cell death in different ways and mitochondrial
dysfunction is an important cause. Astragaloside IV (AIV) is a natural saponin abandent in …
dysfunction is an important cause. Astragaloside IV (AIV) is a natural saponin abandent in …
The role of astragaloside IV against cerebral ischemia/reperfusion injury: suppression of apoptosis via promotion of P62-LC3-autophagy
Y Zhang, Y Zhang, X Jin, X Zhou, X Dong, W Yu… - Molecules, 2019 - mdpi.com
Background: Ischemia/reperfusion (I/R) caused by ischemic stroke treatments leads to brain
injury, and autophagy plays a role in the pathology. Astragaloside IV is a potential …
injury, and autophagy plays a role in the pathology. Astragaloside IV is a potential …
Astragaloside IV alleviates ischemia reperfusion-induced apoptosis by inhibiting the activation of key factors in death receptor pathway and mitochondrial pathway
F Yin, H Zhou, Y Fang, C Li, Y He, L Yu, H Wan… - Journal of …, 2020 - Elsevier
Ethnopharmacological relevance Apoptosis plays an important role in cerebral ischemia-
reperfusion injury and triggers a series of pathological changes which may even be life …
reperfusion injury and triggers a series of pathological changes which may even be life …
Effect of astragaloside IV against rat myocardial cell apoptosis induced by oxidative stress via mitochondrial ATP-sensitive potassium channels
FY Guan, SJ Yang, J Liu… - Molecular Medicine …, 2015 - spandidos-publications.com
Astragaloside is one of the most common traditional Chinese medicines and is derived from
Astragalus membranaceus. Astragaloside IV (AsIV) is a monomer located in an extract of …
Astragalus membranaceus. Astragaloside IV (AsIV) is a monomer located in an extract of …
[HTML][HTML] Astragaloside IV attenuates the H2O2-induced apoptosis of neuronal cells by inhibiting α-synuclein expression via the p38 MAPK pathway
X Liu, J Zhang, S Wang, J Qiu… - … Journal of Molecular …, 2017 - spandidos-publications.com
An oxidative stress insult is one of the principal causes of Parkinson's disease.
Astragaloside IV (AS-IV), a constituent extracted from Astragalus membranaceus, has been …
Astragaloside IV (AS-IV), a constituent extracted from Astragalus membranaceus, has been …
Astragaloside IV inhibits doxorubicin-induced cardiomyocyte apoptosis mediated by mitochondrial apoptotic pathway via activating the PI3K/Akt pathway
Y Jia, D Zuo, Z Li, H Liu, Z Dai, J Cai… - Chemical and …, 2014 - jstage.jst.go.jp
Doxorubicin (DOX) is a widely used antitumor drug whose application is seriously limited by
its cardiotoxicity. Mitochondria-mediated cardiomyocyte apoptosis plays a critical role in …
its cardiotoxicity. Mitochondria-mediated cardiomyocyte apoptosis plays a critical role in …
Isoliquiritigenin isolated from Glycyrrhiza uralensis protects neuronal cells against glutamate-induced mitochondrial dysfunction
EJ Yang, JS Min, HY Ku, HS Choi, M Park… - Biochemical and …, 2012 - Elsevier
Glutamate-mediated excitotoxicity, which is associated with reactive oxygen species (ROS),
is hypothesized to be a major contributor to pathological cell death in the mammalian central …
is hypothesized to be a major contributor to pathological cell death in the mammalian central …
Glycine protects against hypoxic‐ischemic brain injury by regulating mitochondria‐mediated autophagy via the AMPK pathway
C Cai, J Zhu, L Ye, Y Dai, M Fang, Y Hu… - Oxidative medicine …, 2019 - Wiley Online Library
Hypoxic‐ischemic encephalopathy (HIE) is detrimental to newborns and is associated with
high mortality and poor prognosis. Thus, the primary aim of the present study was to …
high mortality and poor prognosis. Thus, the primary aim of the present study was to …
[HTML][HTML] Astragaloside IV protects primary cerebral cortical neurons from oxygen and glucose deprivation/reoxygenation by activating the PKA/CREB pathway
B Xue, J Huang, B Ma, B Yang, D Chang, J Liu - Neuroscience, 2019 - Elsevier
Stroke is one of the major leading causes of death and disability worldwide, and post-stroke
cognitive impairment is a major contributor to this disability. Astragaloside IV (AST-IV) is a …
cognitive impairment is a major contributor to this disability. Astragaloside IV (AST-IV) is a …
RETRACTED: Astragaloside IV reduces the hypoxia-induced injury in PC-12 cells by inhibiting expression of miR-124
W Yu, Z Lv, L Zhang, Z Gao, X Chen, X Yang, M Zhong - 2018 - Elsevier
In 2019, Li and coworkers demonstrated the role of Astragaloside IV (AS-IV) in the in vivo
model to protect the mitochondrial function, ischemic brain tissue damage, and the inhibition …
model to protect the mitochondrial function, ischemic brain tissue damage, and the inhibition …