We have identified an activity that is required for transcription of downstream promoter
element (DPE)–containing core promoters in vitro. The purified factor was found to be the …

Spt2 is a chromatin component with roles in transcription and posttranscriptional regulation.
Recently, we found that Spt2 travels with RNA polymerase II (RNAP II), is involved in …

All cells, from prokaryotes to vertebrates, synthesize vast amounts of ribosomal RNA to
produce the several million new ribosomes per generation that are required to maintain the …

In cells lacking the histone methyltransferase Set2, initiation of RNA polymerase II
transcription occurs inappropriately within the protein-coding regions of genes, rather than …

Mutations in Escherichia coli rpoB or rpoC, selected for the ability to confer prototrophy on
relA spoT strains, were found to affect transcription from rrn P1 promoters. Two mutant …

We recently proposed that a nontemplate strand base in the discriminator region of bacterial
promoters, the region between the− 10 element and the transcription start site, makes …

The amino-terminal region of the double-stranded (ds) RNA-dependent protein kinase, PKR,
has been shown to mediate both dsRNA binding and protein dimerization. To critically …

Some promoters, including the DmpR-controlled ς N-dependent Po promoter, are effectively
rendered silent in cells lacking the nutritional alarmone (p) ppGpp. Here we demonstrate …

The global regulatory nucleotide ppGpp (" magic spot") regulates transcription from a large
subset of Escherichia coli promoters, illustrating how small molecules can control gene …

Protein kinase R (PKR) is a central component of the interferon antiviral defense pathway.
Upon binding double-stranded RNA (dsRNA), PKR undergoes autophosphorylation …