Background: Fibrosis is a hallmark of many myocardial pathologies and contributes to
distorted organ architecture and function. Recent studies have identified premature …

The aging heart is characterized by morphological and structural changes that lead to its
functional decline and are associated with diminished ability to meet increased demand …

Senescence is a recognized mechanism of cardiovascular diseases; however, its
contribution to myocardial fibrosis and rupture after infarction and the underlying …

Heart failure is strongly associated with aging. Elderly patients with heart failure often have
preserved systolic function exhibiting left ventricular hypertrophy accompanied by a decline …

Cardiac fibrosis refers to an excessive deposition of extracellular matrix (ECM) in cardiac
tissue. Fibrotic tissue is stiffer and less compliant, resulting in subsequent cardiac …

Fibrotic diseases are a significant global burden for which there are limited treatment
options. The effector cells of fibrosis are activated fibroblasts called myofibroblasts, a highly …

Cardiac fibrosis is a common pathophysiologic companion of most myocardial diseases,
and is associated with systolic and diastolic dysfunction, arrhythmogenesis, and adverse …

The syncytium of cardiomyocytes in the heart is tethered within a matrix composed
principally of type I fibrillar collagen. The matrix has diverse mechanical functions that …

Background—Two opposite views of cardiac growth are currently held; one views the heart
as a static organ characterized by a large number of cardiomyocytes that are present at birth …

BACKGROUND: Cardiomyopathy is characterized by the pathological accumulation of
resident cardiac fibroblasts that deposit ECM (extracellular matrix) and generate a fibrotic …