The cellular phenomena underlying focal epilepsy are currently understood in the context of
contemporary concepts of cellular and synaptic function. Interictal discharges appear to be …

Intracellular recordings were obtained in the in vitro slice preparation from neurons of lateral
and mesial temporal cortex removed from human epileptics suffering from intractable …

Animal models have provided invaluable data for identifying the pathogenesis of epileptic
disorders. Clearly, the relevance of these experimental findings would be strengthened by …

The origin and mechanisms of human interictal epileptic discharges remain unclear. Here,
we describe a spontaneous, rhythmic activity initiated in the subiculum of slices from patients …

Interictal spikes are a simple kind of epileptic neuronal activity. Field potentials and
intracellular recordings observed during interictal spikes of penicillin-treated slices of the …

Epilepsy is a disorder of brain function characterized by paroxysmal stereotyped alterations
in behavior associated with synchronous excessive discharge in large aggregates of …

In humans temporal lobe epilepsy (TLE) is characterized by recurrent seizures, neuronal
hyperexcitability, and selective loss of certain neuronal populations in the hippocampus …

The occurrence of seizure activity in human temporal lobe epilepsy or status epilepticus is
often associated with a characteristic pattern of cell loss in the hippocampus. An …

The investigation of the mechanisms that cause seizures to suddenly arise in a generalized
fashion all over the brain has received less attention in epilepsy research than studies on …

▪ Abstract The highly interconnected networks of the mammalian forebrain can generate a
wide variety of synchronized activities, including those underlying epileptic seizures, which …