Podophyllotoxin and its related aryltetralin cyclolignans belong to a family of important
products that exhibit various biological properties (eg, cytotoxic, insecticidal, antifungal …

Podophyllotoxin, along with its various derivatives and congeners are widely recognized as
broad-spectrum pharmacologically active compounds. Etoposide, for instance, is the …

Podophyllotoxin is an antimitotic natural product. Its inhibitory activity on cell growth led to
the development of the clinically valuable anticancer agents, etoposide, teniposide and the …

Several podophyllotoxin derivatives modified in the A, B, C, D and E rings were prepared
from podophyllotoxin and methyl isoxazopodophyllic acid and evaluated for their cytotoxicity …

To block epimerization and the resulting biological deactivationof podophyllotoxin
compounds, the lactone carbonyl group has been changed tomethylene. Syntheses of …

Podophyllotoxin, one of the well-known naturally occurring aryltetralin lignans, has been
used as the leadcompound for the preparation of potent anticancer agents, such as …

Podophyllotoxin and some of its derivatives are cyclolignans currently used for removing
warts and in the clinical treatment of malign neoplasms. As such, they have been an …

Podophyllotoxin is a naturally occurring lignan with important antineoplastic and antiviral
properties and supported by detailed understanding of their mechanism of action, and …

Podophyllum hexandrum Royle of family Berberidaceae is an endangered medicinal plant.
Rhizome of P. hexandrum contains several lignans which posses antitumor activity …

Manganese dioxide converts podophyllotoxin and picropodophyllin to the corresponding
ketones, podophyllotoxone and picropodophyllone. The ketones with sodium borohydride …