Redox biology of the intestine
ML Circu, TY Aw - Free radical research, 2011 - Taylor & Francis
The intestinal tract, known for its capability for self-renew, represents the first barrier of
defence between the organism and its luminal environment. The thiol/disulfide redox …
defence between the organism and its luminal environment. The thiol/disulfide redox …
Intestinal redox biology and oxidative stress
ML Circu, TY Aw - Seminars in cell & developmental biology, 2012 - Elsevier
The intestinal epithelium sits at the interface between an organism and its luminal
environment, and as such is prone to oxidative damage induced by luminal oxidants …
environment, and as such is prone to oxidative damage induced by luminal oxidants …
Control and dysregulation of redox signalling in the gastrointestinal tract
EL Campbell, SP Colgan - Nature Reviews Gastroenterology & …, 2019 - nature.com
Redox signalling in the gastrointestinal mucosa is held in an intricate balance. Potent
microbicidal mechanisms can be used by infiltrating immune cells, such as neutrophils, to …
microbicidal mechanisms can be used by infiltrating immune cells, such as neutrophils, to …
Role of oxygen gradients in shaping redox relationships between the human intestine and its microbiota
MG Espey - Free Radical Biology and Medicine, 2013 - Elsevier
The unique anatomy and physiology of the intestine in conjunction with its microbial content
create the steepest oxygen gradients in the body, which plunge to near anoxia at the luminal …
create the steepest oxygen gradients in the body, which plunge to near anoxia at the luminal …
Cellular redox: a modulator of intestinal epithelial cell proliferation
TY Aw - Physiology, 2003 - journals.physiology.org
Mucosal proliferation, together with differentiation and apoptosis, are a continuous
homeostatic process in the intestinal epithelium. The glutathione/glutathione disulfide redox …
homeostatic process in the intestinal epithelium. The glutathione/glutathione disulfide redox …
[HTML][HTML] The influence of gut microbiota on oxidative stress and the immune system
C Kunst, S Schmid, M Michalski, D Tümen… - Biomedicines, 2023 - mdpi.com
The human gastrointestinal tract is home to a complex microbial community that plays an
important role in the general well-being of the entire organism. The gut microbiota generates …
important role in the general well-being of the entire organism. The gut microbiota generates …
Inflammatory bowel disease: mechanisms, redox considerations, and therapeutic targets
F Biasi, G Leonarduzzi, PI Oteiza… - Antioxidants & redox …, 2013 - liebertpub.com
Oxidative stress is thought to play a key role in the development of intestinal damage in
inflammatory bowel disease (IBD), because of its primary involvement in intestinal cells' …
inflammatory bowel disease (IBD), because of its primary involvement in intestinal cells' …
Redox signaling in the gastrointestinal tract
S Pérez, R Taléns-Visconti, S Rius-Pérez… - Free Radical Biology …, 2017 - Elsevier
Redox signaling regulates physiological self-renewal, proliferation, migration and
differentiation in gastrointestinal epithelium by modulating Wnt/β-catenin and Notch …
differentiation in gastrointestinal epithelium by modulating Wnt/β-catenin and Notch …
Redox signaling mediates symbiosis between the gut microbiota and the intestine
The microbiota that populates the intestinal tract affects many physiological processes, such
as cell proliferation, epithelial barrier function, and immune responses. However, the …
as cell proliferation, epithelial barrier function, and immune responses. However, the …
Oxidative stress and gut microbiota
F Marciano, P Vajro - Gastrointestinal tissue, 2017 - Elsevier
Gut epithelia and other cell types contacted by enteric commensal bacteria generate
reactive oxygen species (ROS) in response to microbial signals. Physiologically generated …
reactive oxygen species (ROS) in response to microbial signals. Physiologically generated …