The liver X receptors (LXRα and LXRβ) are nuclear receptor transcription factors that are
activated by certain oxysterol derivatives of cholesterol. As such, LXR activity may be up …

Liver X receptors (LXRs) α and β are transcriptional regulators of cholesterol homeostasis
and potential targets for the development of antiatherosclerosis drugs. However, the specific …

Abstract Liver X Receptors (LXRs) α and β are oxysterol-activated nuclear receptors
involved in the control of lipid metabolism and inflammation. Pharmacological activation of …

First discovered as orphan receptors, liver X receptors (LXRs) were subsequently identified
as the nuclear receptor target of the cholesterol metabolites, oxysterols. There are 2 LXR …

The nuclear oxysterol receptors LXRα (NR1H3) and LXRβ (NR1H2) coordinately regulate
the expression of genes involved in the transport and catabolism of cholesterol. In …

Cholesterol is an important lipid for maintaining cell membrane fluidity and generation of
various hormones and bile acids. Thus, it is critical to maintain cholesterol homeostasis …

Liver X receptor (LXR) agonists increase both total fecal sterol excretion and macrophage-
specific reverse cholesterol transport (RCT) in vivo. In this study, we assessed the effects of …

The effects of liver X receptor (LXR) agonists on plasma lipid homeostasis, especially
triglyceride metabolism are controversial. Here we examined the effect of long-term …

Objective—Complications of atherosclerotic cardiovascular disease due to elevated blood
cholesterol levels are the major cause of death in the Western world. The liver X receptors …

Liver X receptor (LXR) α and LXRβ are closely related nuclear receptors that respond to
elevated levels of intracellular cholesterol by enhancing transcription of genes that control …