Cefiderocol: systematic review of mechanisms of resistance, heteroresistance and in vivo emergence of resistance
S Karakonstantis, M Rousaki, EI Kritsotakis - Antibiotics, 2022 - mdpi.com
Cefiderocol appears promising, as it can overcome most β-lactam resistance mechanisms
(including β-lactamases, porin mutations, and efflux pumps). Resistance is uncommon …
(including β-lactamases, porin mutations, and efflux pumps). Resistance is uncommon …
Cefiderocol: An Overview of Its in-vitro and in-vivo Activity and Underlying Resistant Mechanisms
J Yao, J Wang, M Chen, Y Cai - Frontiers in medicine, 2021 - frontiersin.org
Treatment of multidrug-resistant (MDR) Gram-negative bacteria (GNB) infections has led to a
global public health challenging due to the bacterial resistance and limited choices of …
global public health challenging due to the bacterial resistance and limited choices of …
New perspectives on antimicrobial agents: cefiderocol
Bacterial resistance to carbapenem agents has reached alarming levels. Accordingly,
collaborative efforts between national and international organizations and the …
collaborative efforts between national and international organizations and the …
Evolution of β-lactamase-mediated cefiderocol resistance
Background Cefiderocol is a novel siderophore β-lactam with improved hydrolytic stability
toward β-lactamases, including carbapenemases, achieved by combining structural …
toward β-lactamases, including carbapenemases, achieved by combining structural …
Mechanisms of reduced susceptibility to cefiderocol among isolates from the CREDIBLE-CR and APEKS-NP clinical trials
The objective of this study was to characterize isolates with reduced susceptibility to
cefiderocol in patients receiving cefiderocol for nosocomial pneumonia or carbapenem …
cefiderocol in patients receiving cefiderocol for nosocomial pneumonia or carbapenem …
Defining baseline mechanisms of cefiderocol resistance in the Enterobacterales
The objective of this study was to identify putative mechanisms contributing to baseline
cefiderocol resistance among carbapenem-resistant Enterobacterales (CRE). We evaluated …
cefiderocol resistance among carbapenem-resistant Enterobacterales (CRE). We evaluated …
Occurrence of high levels of cefiderocol resistance in carbapenem-resistant Escherichia coli before its approval in China: a report from China CRE-network
Q Wang, L Jin, S Sun, Y Yin, R Wang, F Chen… - Microbiology …, 2022 - Am Soc Microbiol
Cefiderocol has been approved in the United States and Europe but not in China. We aim to
evaluate carbapenem-resistant Enterobacterales (CRE) susceptibility to cefiderocol to …
evaluate carbapenem-resistant Enterobacterales (CRE) susceptibility to cefiderocol to …
In vitro activity of cefiderocol against a broad range of clinically important Gram-negative bacteria
Y Yamano - Clinical Infectious Diseases, 2019 - academic.oup.com
Carbapenem-resistant gram-negative bacteria including Enterobacteriaceae as well as
nonfermenters, such as Pseudomonas aeruginosa and Acinetobacter baumannii, have …
nonfermenters, such as Pseudomonas aeruginosa and Acinetobacter baumannii, have …
Treatment of carbapenem-resistant Pseudomonas aeruginosa infections: a case for cefiderocol
ABSTRACT Introduction Carbapenem-resistant (CR) Pseudomonas aeruginosa infections
constitute a serious clinical threat globally. Patients are often critically ill and/or …
constitute a serious clinical threat globally. Patients are often critically ill and/or …
Cefiderocol resistance in Acinetobacter baumannii: roles of β-lactamases, siderophore receptors, and penicillin binding protein 3
S Malik, M Kaminski, D Landman… - Antimicrobial agents and …, 2020 - Am Soc Microbiol
Cefiderocol is a siderophore cephalosporin active against many multidrug-resistant (MDR)
Gram-negative pathogens. We examined the resistance mechanisms in 12 Acinetobacter …
Gram-negative pathogens. We examined the resistance mechanisms in 12 Acinetobacter …