Studies over the past 10 years have provided major insights into the molecular mechanisms
responsible for active transport of macromolecules in and out of the nucleus …

The movement of macromolecules between the nucleus and cytoplasm is tightly controlled.
In the past few years it has become increasingly apparent that nuclear traffic is regulated not …

The nuclear envelope encloses most of the cellular DNA and divides the process of gene
expressiontranscription and maturation of RNA molecules occur mostly in the nucleus …

Molecules enter and exit the nucleus of eukaryotic cells through aqueous channels formed
in the nuclear envelope by nuclear pore complexes (NPC). Proteins entering or leaving the …

In eukaryotic cells, the enclosure of the genetic information in the nucleus allows the spatial
and temporal separation of DNA replication and transcription from cytoplasmic protein …

The compartmentalization of DNA in the nucleus of eukaryotic cells establishes a connection
between the nuclear transport machinery and the transcriptional apparatus. General …

Publisher Summary An exchange of molecules between the nucleus and cytoplasm is
indispensable for gene regulation and normal cell growth and development. Transcription of …

Separation of the nucleus and cytoplasm, maintained by two membrane bilayers that form
the nuclear envelope, allows for spatial control over transcription factors and signaling …

The term nuclear transport, refers to the movement of a large variety of macromolecules both
into and out of the nucleus. Transport must be extremely selective, yet also very efficient. A …

The nuclear–cytoplasmic protein transport is a critical process in cellular events. The
identification of transport signals (nuclear localization signal and nuclear export signal) and …