One‐step radiosynthesis of [18F]LBT‐999: a selective radioligand for the visualization of the dopamine transporter with PET

F Dollé, J Helfenbein, F Hinnen, S Mavel… - Journal of Labelled …, 2007 - Wiley Online Library
Abstract LBT‐999 (8‐((E)‐4‐fluoro‐but‐2‐enyl)‐3‐beta‐p‐tolyl‐8‐aza‐bicyclo [3.2. 1]
octane‐2‐beta‐carboxylicacid methyl ester) is a recently developed cocaine derivative …

Synthesis of a Dopamine Transporter Imaging Agent, N-(3-[]fluoropropyl)--carbomethoxy--(4-iodophenyl)nortropane

YS Choe, SJ Oh, DY Chi, SE Kim, Y Choi… - The Korean Journal …, 1999 - koreascience.kr
Purpose: N-(3-[$^{18} F $] Fluoropropyl)-$2 {\beta} $-carbomethoxy-$3 {\beta} $-(4-
iodophenyl) nortropane [$^{18} F $] FP-CIT) has been shown to be very useful for imaging …

Synthesis and Biological Evaluation of [18F]FECNT-d4 as a Novel PET Agent for Dopamine Transporter Imaging

S Cao, J Tang, C Liu, Y Fang, L Ji, Y Xu… - Molecular Imaging and …, 2021 - Springer
Purpose The dopamine transporter (DAT) is a marker of the occurrence and development of
Parkinson's disease (PD) and other diseases with nigrostriatal degeneration. 2β …

[18F]CFT ([18F]WIN 35,428), a radioligand to study the dopamine transporter with PET: Biodistribution in rats

M Haaparanta, J Bergman, A Laakso, J Hietala… - Synapse, 1996 - Wiley Online Library
We describe the 18F‐radiolabelling synthesis (18F; T1/2= 109.8 min) of 2‐β‐carbomethoxy‐
3β‐(4‐fluorophenyl) tropane (also known as CFT or WIN 35,428) and the biodistribution of …

18F-labeled FECNT: a selective radioligand for PET imaging of brain dopamine transporters

MM Goodman, CD Kilts, R Keil, B Shi… - Nuclear medicine and …, 2000 - Elsevier
Fluorine-18 labeled 2β-carbomethoxy-3β-(4-chlorophenyl)-8-(2-fluoroethyl) nortropane
(FECNT) was synthesized in the development of a dopamine transporter (DAT) imaging …

A one-step fully automated radio-synthesis of a dopamine transporter PET imaging agent 18F-FECNT and its in vivo evaluations

S Liang, Z Chen, Y Ma, J Guo, H Wang - Journal of Radioanalytical and …, 2013 - Springer
Abstract 2β-Carbomethoxy-3β-(4-chlorophenyl)-8-(2-[18 F] fluoroethyl) nortropane ([18 F]-
FECNT) is a potential dopamine transporter PET imaging agent. However, its current radio …

Synthesis of novel halo and tosyloxy nortropane derivatives as efficient precursors for the one‐step synthesis of the dopamine transporter PET ligand [18F]FECNT

J Pijarowska‐Kruszyna, AW Jaron… - Journal of Labelled …, 2014 - Wiley Online Library
The fluorine‐18 labeled nortropane derivative 2β‐carbomethoxy‐3β‐(4‐chlorophenyl)‐8‐(2‐
fluoroethyl)‐nortropane (FECNT) is a dopamine transporter (DAT) ligand. Currently, it is …

Synthesis of 3-[18F] fluoromethyl-BTCP and evaluation as a potential PET radioligand for the dopamine transporter in baboons

M Ponchant, M Varastet, P Hantraye… - Nuclear medicine and …, 1993 - Elsevier
In an attempt to visualize in vivo the dopamine transporter and evaluate its potential as an
imaging tool for monitoring dopamine fiber degeneration by positron emission tomography …

Semi-automated preparation of the dopamine transporter ligand [18F] FECNT for human PET imaging studies

RJ Voll, J McConathy, MS Waldrep, RJ Crowe… - Applied radiation and …, 2005 - Elsevier
The fluorine-18 labeled dopamine transport (DAT) ligand 2β-carbomethoxy-3β-(4-
chlorophenyl)-8-(2-fluoroethyl) nortropane (FECNT) has shown promising properties as an …

Synthesis of a fluorine-18-labelled derivative of 6-nitroquipazine, as a radioligand for the in vivo serotonin transporter imaging with PET

M Karramkam, F Dollé, H Valette, L Besret… - Bioorganic & medicinal …, 2002 - Elsevier
Considerable efforts have been engaged in the design, synthesis and pharmacological
characterization of radioligands for imaging the serotonin transporter, based on its …