Application of feedback‐controlled bolus plus infusion (FC‐B/I) method for quantitative PET imaging of dopamine transporters with [18F]β‐CFT‐FE in conscious …

N Harada, H Ohba, T Kakiuchi, H Tsukada - Synapse, 2013 - Wiley Online Library
The competitive inhibition of dopamine transporters (DAT) with cocaine, a specific DAT
inhibitor, was evaluated with a feedback‐controlled bolus plus infusion (FC‐B/I) method …

Synthesis of a dopamine uptake inhibitor for PET studies: 1‐[1‐(2‐benzo(b)thiophenyl)cyclohexyl]‐4‐(2‐[18F]fluoroethyl) piperazine

I Loustau‐Then, M Ponchant… - Journal of Labelled …, 1996 - Wiley Online Library
Abstract The BTCP derivative 1‐[1‐(2‐benzo (b) thiophenyl) cyclohexyl]‐4‐(2‐hydroxyethyl)
piperazine (UNDERLINE) 2 (/UNDERLINE) showed, in vitro, high affinity and selectivity for …

Automated on-line preparation of 11C-β-CFT, a dopamine transporter imaging agent

J Zhang, J Tian, Z Guo, W Ding, S Yao… - Chinese Journal of …, 2005 - inis.iaea.org
[en] Objective: To develop an automatic synthesis method for the on-line preparation of
dopamine transporter imaging agent, 11 C-methyl-N-2-β-carbomethoxy-3-β-(4-fluorophenyl) …

Pharmacological characterization of (E)-N-(4-fluorobut-2-enyl)-2β-carbomethoxy-3β-(4′-tolyl) nortropane (LBT-999) as a highly promising fluorinated ligand for the …

S Chalon, H Hall, W Saba, L Garreau, F Dollé… - … of Pharmacology and …, 2006 - ASPET
In the aim to develop an efficient fluorinated probe for positron emission tomography (PET)
exploration of the dopamine transporter (DAT), we studied several in vitro and in vivo …

Synthesis, biological evaluation and radiolabelling by 18F-fluoroarylation of a dopamine D3-selective ligand as prospective imaging probe for PET

SB Höfling, S Maschauer, H Hübner, P Gmeiner… - Bioorganic & medicinal …, 2010 - Elsevier
Radical 18F-fluoroarylation with fluorine-18-labelled arenediazonium chlorides has been
successfully applied to the radiochemical synthesis of the dopamine D3-selective ligand SH …

Synthesis of high-molar-activity [18F]6-fluoro-l-DOPA suitable for human use via Cu-mediated fluorination of a BPin precursor

AV Mossine, SS Tanzey, AF Brooks, KJ Makaravage… - Nature protocols, 2020 - nature.com
Abstract [18F] 6-fluoro-l-DOPA ([18F] FDOPA) is a diagnostic radiopharmaceutical for
positron emission tomography (PET) imaging that is used to image Parkinson's disease …

PET imaging of dopamine transporter with 18F-LBT999: first human exploration

N Arlicot, J Vercouillie, R BIDAULT, M Serge… - 2017 - Soc Nuclear Med
276 Objectives: Tropane derivatives are well established 123I-ligands for SPECT/CT
imaging of dopamine transporter (DAT) in Parkinson disease (PD) and Lewy body dementia …

Whole Body PET Imaging with a Norepinephrine Transporter Probe 4-[18F]Fluorobenzylguanidine: Biodistribution and Radiation Dosimetry

SJ Lokitz, S Garg, R Nazih, PK Garg - Molecular Imaging and Biology, 2019 - Springer
Abstract Purpose 4-[18 F] Fluorobenzylguanidine ([18 F] PFBG) is a positron emission
tomography (PET) probe for non-invasive targeting of the norepinephrine transporter. The …

In vivo PET quantification of the dopamine transporter in rat brain with [18F] LBT-999

S Sérrière, C Tauber, J Vercouillie, D Guilloteau… - Nuclear Medicine and …, 2014 - Elsevier
Introduction We examined whether [18 F] LBT-999 ((E)-N-(4-fluorobut-2-enyl) 2β-
carbomethoxy-3β-(4'-tolyl) nortropane) is an efficient positron emission tomography (PET) …

Fluorine‐18‐labeled tropane analogs for PET imaging studies of the dopamine transporter

RH Mach, MA Nader, RL Ehrenkaufer, HD Gage… - Synapse, 2000 - Wiley Online Library
A series of PET imaging studies were conducted with two fluorine‐18‐labeled tropane
analoges,[18F](+)‐FTT and [18F](+)‐FCT. Both compounds possessed a high affinity and …