Although the epidemiology of malignant bone tumours in children and young adults has
been explored, no definitive causation of any specific tumour has yet been identified. We …

In a search for etiologic clues to primary bone cancer in childhood, we examined 1,532
death certificates of all children in the United States dying from these neoplasms, 1960–66 …

Background Bone cancers in children are serious and highly fatal conditions, yet relatively
little is known about their causes or methods of prevention. Methods The relationship …

Bone cancers comprise about 5% of childhood neoplasms. Osteosarcoma, the most
common sub‐type, shows a somewhat irregular geographic pattern of incidence, with low …

Osteosarcoma incidence patterns suggest an aetiologic role for perinatal factors, and growth
and development. Osteosarcoma patients (n= 158) and controls with benign orthopaedic …

Background: Malignant bone tumors are a rare group of childhood cancer. Materials and
methods: This study describes incidence rates, survival probabilities, and time trends for …

Abstract Bone tumours comprise 0.2% of cancers overall but 5.7% in 15–24 year olds. To
explore the relationship with adolescence we have analysed age‐incidence patterns of …

There is a paucity of population-based studies examining incidence and survival trends in
childhood bone tumours. We used high quality data from four population-based registries in …

Osteosarcoma derives from primitive bone-forming mesenchymal cells and is the most
common primary bone malignancy. The incidence rates and 95% confidence intervals of …

Background Osteosarcoma typically develops during puberty with tumors arising at sites of
rapid bone growth, suggesting a role for growth‐regulating pathways in tumor etiology …