Overexpression of the flap endonuclease FEN1 has been observed in a variety of cancer
types and is a marker for poor prognosis. To better understand the cellular consequences of …

Abstract Flap endonuclease 1 (Fen1) is a key enzyme for maintaining genetic stability in
eukaryotic genomes. Haploinsufficiency of Fen1 leads to the rapid progression of tumours in …

The flap endonuclease, FEN1, is an evolutionarily conserved component of DNA replication
from archaebacteria to humans. Based on in vitro results, it processes Okazaki fragments …

Human flap endonuclease 1 (FEN1) is a structure-specific, multifunctional endonuclease
essential for DNA replication and repair. Our previous study showed that in response to DNA …

Abstract Flap endonuclease-1 (FEN1) is a multifunctional, structure-specific nuclease that
has a critical role in maintaining human genome stability. FEN1 mutations have been …

Despite the wealth of information available on the biochemical functions and our recent
findings of its roles in genome stability and cancer avoidance of the structure-specific flap …

DNA replication and repair are critical processes for all living organisms to ensure faithful
duplication and transmission of genetic information. Flap endonuclease 1 (Fen1), a structure …

Flap endonuclease 1 (FEN-1) is a 5′–3′ flap exo-/endonuclease that plays an important
role in Okazaki fragment maturation, nonhomologous end joining of double-stranded DNA …

Flap endonuclease-1 (FEN-1) is a multifunctional and structure-specific nuclease that plays
a critical role in maintaining human genome stability through RNA primer removal, long …

Abstract Human flap endonuclease 1 (FEN1) is a structure-specific, multi-functional
endonuclease essential for DNA replication and repair. We and others have shown that …