Adaptation to host temperature is a prerequisite for any pathogen capable of causing deep
infection in humans. Our previous studies demonstrated that a Cryptococcus neoformans …

A common feature shared by systemic fungal pathogens of environmental origin, such as
Cryptococcus neoformans, is their ability to adapt to mammalian core body temperature. In …

Cryptococcus neoformans is an environmental fungus that can cause severe disease in
humans. C. neoformans encounters a multitude of stresses within the human host to which it …

In all eukaryotic cells, the ER stress response is pivotal to survival and adaptation under
stress conditions. During temperature adaptation in the human fungal pathogen …

The capacity of opportunistic fungal pathogens such as Cryptococcus neoformans to cause
disease is dependent on their ability to overcome an onslaught of stresses including …

The pathogenic fungus C ryptococcus neoformans must overcome multiple stressors to
cause disease in its human host. In this study, we report that C. neoformans rapidly and …

The unfolded protein response (UPR) pathway, consisting of the evolutionarily conserved
Ire1 kinase/endonuclease and the bZIP transcription factor Hxl1, is critical for the …

Calcineurin is a conserved calcium/calmodulin-dependent serine/threonine-specific protein
phosphatase that acts in cell stress responses. Calcineurin is essential for growth at 37° C …

Calcineurin is a highly conserved Ca2+/calmodulin-dependent serine/threonine-specific
protein phosphatase that orchestrates cellular Ca2+ signaling responses. In Cryptococcus …

Cryptococcus neoformans is one of the few environmental fungi that can survive within a
mammalian host and cause disease. Although many of the factors responsible for …