Generalized hyperalgesia and impaired pain modulation are reported in chronic low back
pain (LBP). Few studies have tested whether these features are present in the acute phase …

Objectives: Quantitative sensory testing (QST) has been used to elucidate the peripheral
and central mechanisms that underlie changes in pain sensitivity associated with low back …

Central sensitization is considered to have a pathophysiological role in chronic low back
pain (LBP). Whether individuals with increased central sensitization early in their condition …

Objective. Research on chronic low back pain (cLBP) has focused heavily on structural
abnormalities with emphasis on diagnostic imaging. However, for many cLBP patients …

Objectives: Disturbed endogenous pain modulation is likely one of the mechanisms
underlying central hypersensitivity and might be a contributing factor for the development …

Objectives: Low back pain (LBP) is the second most frequently diagnosed pain condition in
the United States, and although a majority of individuals have resolution of pain during the …

Objectives: Despite its impact, individual factors associated with persistent low back pain
(LBP) remain poorly understood. This study investigated static and dynamic pain sensitivity …

Objectives: Widespread central hypersensitivity and altered conditioned pain modulation
(CPM) have been documented in chronic pain conditions. Information on their prognostic …

Objective. Several studies have shown that exposure to opioids for short or long periods
alters pain sensitivity. Little is known about changes in pain sensitivity during and after …

Objectives: This exploratory study aimed to investigate the temporal development of
somatosensory changes from the acute stage of LBP to up to 4 months from onset. Methods …