A tolC Mutant of Francisella tularensis Is Hypercytotoxic Compared to the Wild Type and Elicits Increased Proinflammatory Responses from Host Cells

GJ Platz, DAC Bublitz, P Mena, JL Benach… - Infection and …, 2010 - Am Soc Microbiol
The highly infectious bacterium Francisella tularensis is a facultative intracellular pathogen
and the causative agent of tularemia. TolC, which is an outer membrane protein involved in …

TolC-dependent modulation of host cell death by the Francisella tularensis live vaccine strain

CR Doyle, JA Pan, P Mena, WX Zong… - Infection and …, 2014 - Am Soc Microbiol
Francisella tularensis is a facultative intracellular, Gram-negative pathogen and the
causative agent of tularemia. We previously identified TolC as a virulence factor of the F …

Deletion of TolC orthologs in Francisella tularensis identifies roles in multidrug resistance and virulence

H Gil, GJ Platz, CA Forestal, M Monfett… - Proceedings of the …, 2006 - National Acad Sciences
The Gram-negative bacterium Francisella tularensis is the causative agent of tularemia.
Interest in this zoonotic pathogen has increased due to its classification as a category A …

Expression of IglC is necessary for intracellular growth and induction of apoptosis in murine macrophages by Francisella tularensis

XH Lai, I Golovliov, A Sjöstedt - Microbial pathogenesis, 2004 - Elsevier
Francisella tularensis is a facultative intracellular bacterium capable of inducing apoptosis in
murine macrophages. In a previous study, an iglC null mutant of F. tularensis live vaccine …

Francisella tularensis LVS initially activates but subsequently down-regulates intracellular signaling and cytokine secretion in mouse monocytic and human peripheral …

M Telepnev, I Golovliov, A Sjöstedt - Microbial pathogenesis, 2005 - Elsevier
Monocytic cells constitute an important defense mechanism against invading pathogens by
recognizing conserved pathogens components. The recognition leads to activation of …

A conserved and immunodominant lipoprotein of Francisella tularensis is proinflammatory but not essential for virulence

CA Forestal, H Gil, M Monfett, CE Noah, GJ Platz… - Microbial …, 2008 - Elsevier
Francisella tularensis is a highly virulent bacterium that causes tularemia, a disease that is
often fatal if untreated. A live vaccine strain (LVS) of this bacterium is attenuated for virulence …

Toll-Like Receptor 2 Is Required for Inflammatory Responses to Francisella tularensis LVS

J Katz, P Zhang, M Martin, SN Vogel… - Infection and …, 2006 - Am Soc Microbiol
Francisella tularensis, a gram-negative bacterium, is the etiologic agent of tularemia and has
recently been classified as a category A bioterrorism agent. Infections with F. tularensis …

Innate immune response to Francisella tularensis is mediated by TLR2 and caspase-1 activation

H Li, S Nookala, XR Bina, JE Bina… - Journal of leukocyte …, 2006 - academic.oup.com
Francisella tularensis, a gram-negative, facultative, intracellular bacterium, is the etiologic
agent of tularemia and a category A bioterrorism agent. Little is known about the mechanism …

Toll-Like Receptor 2-Mediated Signaling Requirements for Francisella tularensis Live Vaccine Strain Infection of Murine Macrophages

LE Cole, KA Shirey, E Barry, A Santiago… - Infection and …, 2007 - Am Soc Microbiol
Francisella tularensis, an aerobic, non-spore-forming, gram-negative coccobacillus, is the
causative agent of tularemia. We reported previously that F. tularensis live vaccine strain …

[HTML][HTML] The capBCA Locus is Required for Intracellular Growth of Francisella tularensis LVS

J Su, R Asare, J Yang, MKM Nair… - Frontiers in …, 2011 - frontiersin.org
Francisella tularensis is the causative agent of tularemia and a category A bioterrorism
agent. The molecular basis for the extreme virulence of F. tularensis remains unclear. Our …