The most widely used formalin test to screen antinociceptive drug candidates is still
apostrophized as targeting inflammatory pain, in spite of strong opposing evidence …

Although the formalin test is a widely used model of persistent pain, the primary afferent fiber
types that underlie the cellular and behavioral responses to formalin injection are largely …

The formalin test was originally developed by Dubuisson and Dennis (1977), and has since
been extensively used to assess pain-related responses. Rats and mice are the most …

Formalin injected subcutaneously into the paw is a frequently used pain assay; it evokes an
initial period of licking and flinching followed by a period of quiescence and last by a second …

The formalin test still surprises with its biphasic pain-related behavior resulting from a
quiescent interphase that does not occur with other algogenic compounds and remains …

The formalin test in mice is a valid and reliable model of nociception and is sensitive for
various classes of analgesic drugs. The noxious stimulus is an injection of dilute formalin …

The orofacial formalin test in the rat is a valid and reliable model of nociception and is
sensitive to various classes of analgesic drugs. The noxious stimulus consists in an injection …

The formalin test was introduced as a model of tonic pain in 1977, and has since been used
extensively in rats and mice. In rats, formalin generates an initial phase of activity (5–10 min …

The formalin test is the most widely used behavioral screening test for analgesic
compounds. The cellular mechanism of action of formaldehyde, inducing a typically biphasic …

The effect of different formalin concentrations on the nociceptive response in the formalin
test was examined in mice. Subcutaneous formalin injection induces 2 distinct periods of …