Subcutaneous formalin injection is widely used as a nociceptive stimulus in the rat. This
procedure evokes overt behaviors that last about 90 minutes. However, little is known about …

We investigated the scoring properties of the mouse formalin test using the time-sampling
method recently developed for infant and adult rats. Formalin was injected under the plantar …

The ambient temperature had a confounding influence on the licking response in the
formalin test. No effect was demonstrated in the early phase. In the late phase, the licking …

The formalin test for nociception, which is predominantly used with rats and mice, involves
moderate, continuous pain generated by injured tissue. In this way it differs from most …

Systemic capsaicin and an analogue, olvanil (NE-19550, 4-hydroxy-3-methoxyphenyl
methyl-9Z-octadecenamide), were tested for antinociceptive activity in a model of persistent …

The effects of local treatment with opioid receptor agonists on the early (0–10 min) and late
(20–40 min) behavioural response and extravasation induced by intraplantar injection of 1 …

Subcutaneous injection of dilute formalin induces pain in humans and behaviors indicative
of pain in animals. The formalin test, which is based on these observations, is now widely …

This study examines the dose dependent analgesic effects of two doses of morphine and a
single dose of alfentanil on experimentally induced cutaneous pain. In 16 healthy volunteers …

Methods: In this study, we compared nociceptive behaviors induced by formalin injections
(2%, 4%, and 8%) into either glabrous skin (plantar surface) of the hind paw or hairy skin of …

The formalin test is an important means of assessing pain evoked-behaviours induced by
moderately intense and long-lasting noxious stimuli, yet the procedures for performing the …