Interleukin-1 blockade in cardiovascular diseases: a clinical update

LF Buckley, A Abbate - European heart journal, 2018 - academic.oup.com
Abstract Interleukin-1 (IL-1) is the prototypical pro-inflammatory cytokine. IL-1 was implicated
as a cardiodepressant factor in septic shock, and subsequent pre-clinical and clinical …

Interleukin-1 trap attenuates cardiac remodeling after experimental acute myocardial infarction in mice

BW Van Tassell, A Varma, FN Salloum… - Journal of …, 2010 - journals.lww.com
Background: Interleukin-1 (IL-1) is an inflammatory cytokine that responds as an acute
phase reactant during acute myocardial infarction. Conflicting data describe the role of anti …

Interleukin‐6 and the risk of adverse outcomes in patients after an acute coronary syndrome: observations from the SOLID‐TIMI 52 (stabilization of plaque using …

CL Fanola, DA Morrow, CP Cannon… - Journal of the …, 2017 - Am Heart Assoc
Background Interleukin‐6 (IL‐6) is an inflammatory cytokine implicated in plaque instability
in acute coronary syndrome (ACS). We aimed to evaluate the prognostic implications of IL‐6 …

Interleukin 8 released after acute myocardial infarction is mainly bound to erythrocytes

RJ de Winter, A Manten, YP de Jong, R Adams… - Heart, 1997 - heart.bmj.com
Objective To determine whether rapid clearance of interleukin 8 (IL-8) from plasma through
binding to the erythrocyte chemokine receptor may be responsible for failure to detect IL-8 …

The role of interleukin-1 in the failing heart

CS Long - Heart failure reviews, 2001 - Springer
The prevalance of congestive heart failure and its continued poor prognosis despite
presently available therapeutic options emphasize the importance of pursuing the …

Anakinra, a recombinant human interleukin-1 receptor antagonist, inhibits apoptosis in experimental acute myocardial infarction

A Abbate, FN Salloum, E Vecile, A Das, NN Hoke… - Circulation, 2008 - Am Heart Assoc
Background—Experimental interleukin-1 receptor antagonist gene overexpression has
shown that interleukin-1 receptor antagonist is cardioprotective during global cardiac …

Interleukin-6 and interleukin-8 concentrations as predictors of outcome in ventricular assist device patients before heart transplantation

M HUMMEL, S CZERLINSKI, N FRIEDEL… - Critical care …, 1994 - journals.lww.com
Objective: To determine whether the serum concentrations of some circulating cytokines (as
highly sensitive markers of inflammation) are of value in predicting the outcome of patients …

Anakinra in experimental acute myocardial infarction—does dosage or duration of treatment matter?

FN Salloum, V Chau, A Varma, NN Hoke… - … drugs and therapy, 2009 - Springer
Abstract Purpose Interleukin-1 (IL-1) receptor antagonist (Ra) is a naturally occurring IL-1
blocker with a cardioprotective effect during acute myocardial infarction (AMI). Anakinra …

High circulating levels of interleukin-6 in patients with septic shock: evolution during sepsis, prognostic value, and interplay with other cytokines

T Calandra, J Gerain, D Heumann… - The American journal of …, 1991 - Elsevier
Abstract purpose and patients: We measured the serum concentrations of interleukin-6 (IL-6)
in 70 patients with established septic shock caused predominantly by gram-negative …

Myocardial dysfunction and shock after cardiac arrest

JC Jentzer, MD Chonde… - BioMed research …, 2015 - Wiley Online Library
Postarrest myocardial dysfunction includes the development of low cardiac output or
ventricular systolic or diastolic dysfunction after cardiac arrest. Impaired left ventricular …