[HTML][HTML] Translational overview of cytokine inhibition in acute myocardial infarction and chronic heart failure
MHT Hartman, HE Groot, IM Leach, JC Karper… - Trends in cardiovascular …, 2018 - Elsevier
Many cytokines are currently under investigation as potential target to improve cardiac
function and outcome in the setting of acute myocardial infarction (MI) or chronic heart failure …
function and outcome in the setting of acute myocardial infarction (MI) or chronic heart failure …
A review of interleukin-1 in heart disease: where do we stand today?
Y Szekely, Y Arbel - Cardiology and therapy, 2018 - Springer
Cardiovascular diseases are the leading cause of death worldwide. Research in the last two
decades has emphasized the inflammatory process as a key component in the …
decades has emphasized the inflammatory process as a key component in the …
Association of interleukin 8 and myocardial recovery in patients with ST-elevation myocardial infarction complicated by acute heart failure
T Husebye, J Eritsland, H Arnesen, R Bjørnerheim… - PloS one, 2014 - journals.plos.org
Background No data from controlled trials exists regarding the inflammatory response in
patients with de novo heart failure (HF) complicating ST-elevation myocardial infarction …
patients with de novo heart failure (HF) complicating ST-elevation myocardial infarction …
Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality
MF Osuchowski, K Welch, J Siddiqui… - The Journal of …, 2006 - journals.aai.org
Mortality in sepsis remains unacceptably high and attempts to modulate the inflammatory
response failed to improve survival. Previous reports postulated that the sepsis-triggered …
response failed to improve survival. Previous reports postulated that the sepsis-triggered …
Randomized, placebo-controlled trial of the anti-tumor necrosis factor antibody fragment afelimomab in hyperinflammatory response during severe sepsis: The …
K Reinhart, T Menges, B Gardlund… - Critical care …, 2001 - journals.lww.com
Randomized, placebo-controlled trial of the anti-tumor necro... : Critical Care Medicine
Randomized, placebo-controlled trial of the anti-tumor necrosis factor antibody fragment …
Randomized, placebo-controlled trial of the anti-tumor necrosis factor antibody fragment …
Inhibition of interleukin-6 receptor in a murine model of myocardial ischemia-reperfusion
MHT Hartman, I Vreeswijk-Baudoin, HE Groot… - PloS one, 2016 - journals.plos.org
Background Interleukin-6 (IL-6) levels are upregulated in myocardial infarction. Recent data
suggest a causal role of the IL-6 receptor (IL-6R) in coronary heart disease. We evaluated if …
suggest a causal role of the IL-6 receptor (IL-6R) in coronary heart disease. We evaluated if …
Targeting interleukin-1 in heart disease
Van Tassell et al IL-1 and Heart Disease 1911 progression of coronary artery disease and
impaired function. Nevertheless, reports of an inflammatory response during heart disease …
impaired function. Nevertheless, reports of an inflammatory response during heart disease …
Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F (ab′) 2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 …
Objective: To evaluate whether administration of afelimomab, an anti-tumor necrosis factor F
(ab′) 2 monoclonal antibody fragment, would reduce 28-day all-cause mortality in patients …
(ab′) 2 monoclonal antibody fragment, would reduce 28-day all-cause mortality in patients …
Initial evaluation of human recombinant interleukin-1 receptor antagonist in the treatment of sepsis syndrome: a randomized, open-label, placebocontrolled …
CJ Fisher Jr, GJ Slotman, SM Opal, JP Pribble… - Critical care …, 1994 - journals.lww.com
Objectives: To evaluate the safety, pharmacokinetics, and efficacy of human recombinant
interleukin-1 receptor antagonist (IL-lra) in the treatment of patients with sepsis syndrome …
interleukin-1 receptor antagonist (IL-lra) in the treatment of patients with sepsis syndrome …
Interleukin‐1 blockade inhibits the acute inflammatory response in patients with ST‐segment–elevation myocardial infarction
Background ST‐segment–elevation myocardial infarction is associated with an intense
acute inflammatory response and risk of heart failure. We tested whether interleukin‐1 …
acute inflammatory response and risk of heart failure. We tested whether interleukin‐1 …