Abstract Background The interleukin-6 (IL-6) pathway has a crucial role in the pathogenesis
of atherosclerosis, the main cause of cardiovascular diseases. We aimed to characterize the …

Background—Experimental interleukin-1 receptor antagonist gene overexpression has
shown that interleukin-1 receptor antagonist is cardioprotective during global cardiac …

Extensive investigations have implicated cytokines such as tumour necrosis factor (TNF)-α
and interleukin (IL)-1, and IL-6 as contributing to the pathology of ischemia-reperfusion (I/R) …

Increased levels of interleukin-6 (IL-6) have been observed in patients with acute
myocarditis and are associated with poor prognosis. This study was designed to examine …

Sepsis remains a major cause of morbidity and mortality in most intensive care units.
Protracted sepsis can evolve into a state of profound immunosuppression characterized by …

BACKGROUND: Inflammatory mechanisms in heart disease are of great interest. The
proinflammatory cytokine interleukin (IL) 6 has been linked to increased morbidity in …

Abstract Interleukin-1 (IL-1) is a highly active pro-inflammatory cytokine that lowers pain
thresholds and damages tissues. Monotherapy blocking IL-1 activity in autoinflammatory …

PURPOSE: Although animal studies document conflicting data on the influence of
hypothermia on cytokine release in various settings, no data exist if hypothermia affects the …

Bacterial products [lipopolysaccharide (LPS) with Gram-negative bacteria and toxins,
superantigens or cell wall fragments with Gram-positive bacteria] are the main activators of …

IL-18, originally termed as interferon γ (IFN-γ) inducing factor, is a proinflammatory cytokine
that belongs to the IL-1 cytokine superfamily. IL-18 plays an important role in immune …