The hypoxia-inducible transcription factors (HIFs) play a central role in the response of cells
to hypoxia. HIFs are αβ dimers, the human α subunit having three isoforms. HIF-3α is unique …

HIF (hypoxia-inducible factor)-3α is the third member of the HIF transcription factor family.
Whereas HIF-1α and-2α play critical roles in the cellular and systemic adaptation to hypoxia …

The hypoxia-inducible transcription factor (HIF) controls (in an oxygen-dependent manner)
the expression of a large number of genes whose products are involved in the response of …

Hypoxia inducible factors (HIFs) are transcription factors, which are commonly expressed in
mammals, including humans. The HIFs consist of hypoxia-regulated α and oxygen …

ABSTRACT A universal response to changes in cellular oxygen tension is governed by a
family of heterodimeric transcription factors called hypoxia‐inducible factor (HIF). Tumor …

Cellular integrity in hypoxia is dependent on molecular adaptations dominated by the
heterodimeric transcription factor hypoxia-inducible factor (HIF). The HIF complex contains …

Hypoxia‐inducible factors (HIF s) are key regulators of the transcriptional response to
hypoxic stress. Three inducible isoforms of HIF are present in mammals. HIF 1α and HIF 2α …

Hypoxia‐inducible factor 1 (HIF‐1) is a transcriptional activator of various genes related to
cellular adaptive responses to hypoxia. Dysfunctions in the regulatory systems of HIF‐1 …

Hypoxia-inducible factors (HIFs) play key roles in the cellular response to hypoxia. It is
widely accepted that whereas HIF-1 and HIF-2 function as transcriptional activators, HIF-3 …

Abstract Hypoxia inducible factor (HIF)-1 and HIF-2 are heterodimeric transcription factors
mediating the cellular response to hypoxia. Recent data indicate that not only ubiquitous HIF …