Cdc48 (also called VCP and p97) is an abundant protein that plays essential regulatory
functions in a broad array of cellular processes. Working with various cofactors, Cdc48 …

Abstract Dynamin-related protein (Drp) 1 is a key regulator of mitochondrial fission and is
composed of GTP-binding, Middle, insert B, and C-terminal GTPase effector (GED) domains …

Valosin-containing protein, VCP/p97 or Cdc48, is a eukaryotic ATPase involved in
membrane fusion, protein transport, and protein degradation. We describe two proteins …

Cdc48 (also known as p97), a conserved chaperone-like ATPase, plays a strategic role in
the ubiquitin system,,. Empowered by ATP-driven conformational changes, Cdc48 acts as a …

Specificity of protein ubiquitylation is conferred by E3 ubiquitin (Ub) ligases. We have
annotated∼ 617 putative E3s and substrate-recognition subunits of E3 complexes encoded …

Mitochondria are dynamic organelles that constantly fuse and divide. These processes
(collectively termed mitochondrial dynamics) are important for mitochondrial inheritance and …

Mitochondrial fusion and structure depend on the dynamin-like GTPase OPA1, whose
activity is regulated by proteolytic processing. Constitutive OPA1 cleavage by YME1L and …

Mitochondrial dynamics is important for life. At center stage for mitochondrial dynamics, the
balance between mitochondrial fission and fusion is a set of dynamin‐related GTP ases that …

Fusion controls mitochondrial morphology and is important for normal mitochondrial
function, including roles in respiration, development, and apoptosis. Key components of the …

Mitochondrial fusion and fission tailors the mitochondrial shape to changes in cellular
homeostasis. Players of this process are the mitofusins, which regulate fusion of the outer …