The yeast AAA-ATPase Cdc48 and the ubiquitin fusion degradation (UFD) proteins play
important, evolutionarily conserved roles in ubiquitin dependent protein degradation. The N …

Known activities of the ubiquitin‐selective AAA ATPase Cdc48 (p97) require one of the
mutually exclusive cofactors Ufd1/Npl4 and Shp1 (p47). Whereas Ufd1/Npl4 recruits Cdc48 …

It has been over 20 years since the identification of the first GTPases that regulate
mitochondrial fusion in drosophila, yeast, and mammalian cells. While the molecular …

Mitochondrial shaping proteins are categorized as fusion and fission factors based on their
opposing actions on the architecture of mitochondria. Mammalian Fis1 fragments …

Mitochondria are dynamic organelles engaged in quality control and aging processes. They
constantly undergo fusion, fission, transport, and anchoring events, which empower …

Mitochondria constantly divide and combine through fission and fusion activities. MARCH5,
a mitochondrial E3 ubiquitin ligase, has been identified as a molecule that binds …

Mitochondria are dynamic organelles that alter their morphology in response to cellular
signaling and differentiation through balanced fusion and fission. In this study, we found that …

Gp78 is an ERAD-associated E3 ubiquitin ligase that induces degradation of the mitofusin
mitochondrial fusion proteins and mitochondrial fission. Gp78 is localized throughout the …

Clearance of damaged mitochondria through mitophagy is critical for maintaining
mitochondrial fidelity and the prevention of neurodegeneration. Here, we report on the UBX …

Regulated protein degradation mediated by the ubiquitin-proteasome system (UPS) is
critical to eukaryotic protein homeostasis. Often vital to degradation of protein substrates is …