Mitochondria are dynamic organelles whose shape is regulated by the opposing processes
of fission and fusion, operating in conjunction with organelle distribution along the …

Mitochondria are dynamic organelles that undergo fusion and fission in response to various
physiological and stress stimuli, which play key roles in diverse mitochondrial functions such …

Mitochondria form intricate networks through fission and fusion events. Here, we identify
mitochondrial dynamics proteins of 49 and 51 kDa (MiD49 and MiD51, respectively) …

A broad range of cellular processes are regulated by proteolytic events. Proteolysis has now
also been established to control mitochondrial morphology which results from the balanced …

Mutations or sequence aberrations in the Parkin gene are among the most common causes
of autosomal recessive Parkinson's disorder (PD). Parkin, a cytoplasmic E3 ubiquitin ligase …

Mitochondrial morphology is dynamically regulated by fusion and fission. Several GTP ase
proteins control fusion and fission, and posttranslational modifications of these proteins are …

Cdc48/p97 is an evolutionary conserved ubiquitin-dependent chaperone involved in a
broad array of cellular functions due to its ability to associate with multiple cofactors. Aside …

Many polyubiquitinated proteins are extracted from membranes or complexes by the
conserved ATPase Cdc48 (in yeast; p97 or VCP in mammals) before proteasomal …

In the ubiquitin-proteasome system, a subset of ubiquitylated proteins requires the AAA+
ATPase p97 (also known as VCP or Cdc48) for extraction from membranes or protein …

Mitochondria are essential for a variety of cellular functions, including ATP production, lipid
biosynthesis, and calcium homeostasis. Moreover, a number of major cell signaling …