The participation of galanin in pain processing at the spinal level
Abstract Galanin, a 29-amino-acid peptide expressed in dorsal root ganglia (DRG) and
spinal dorsal horn interneurones, is regulated by nerve injury and peripheral inflammation …
spinal dorsal horn interneurones, is regulated by nerve injury and peripheral inflammation …
Galanin and spinal nociceptive mechanisms: recent advances and therapeutic implications
XJ Xu, T Hökfelt, T Bartfai, Z Wiesenfeld-Hallin - Neuropeptides, 2000 - Elsevier
Galanin is a peptide consisting of 29 or 30 (in humans) amino acids that is present in
sensory and spinal dorsal horn neurons. Endogenous galanin may have an important …
sensory and spinal dorsal horn neurons. Endogenous galanin may have an important …
Galanin and spinal nociceptive mechanisms: recent results from transgenic and knock-out models
Z Wiesenfeld-Hallin, XJ Xu, JN Crawley, T Hökfelt - Neuropeptides, 2005 - Elsevier
Genetically modified mice with transgenic overexpression of galanin or depletion of genes
for galanin or galanin receptors have become available, providing a new approach for …
for galanin or galanin receptors have become available, providing a new approach for …
Transgenic overexpression of galanin in the dorsal root ganglia modulates pain-related behavior
FE Holmes, A Bacon, RJP Pope… - Proceedings of the …, 2003 - National Acad Sciences
The neuropeptide galanin is expressed in the dorsal root ganglia (DRG) and spinal cord and
is thought to be involved in the modulation of pain processing. However, its mechanisms of …
is thought to be involved in the modulation of pain processing. However, its mechanisms of …
Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via GalR1 and GalR2 receptors
Galanin is a 29-aa neuropeptide with a complex role in pain processing. Several galanin
receptor subtypes are present in dorsal root ganglia and spinal cord with a differential …
receptor subtypes are present in dorsal root ganglia and spinal cord with a differential …
Sensory neuronal phenotype in galanin receptor 2 knockout mice: focus on dorsal root ganglion neurone development and pain behaviour
TJS Shi, X Hua, X Lu, S Malkmus… - European Journal of …, 2006 - Wiley Online Library
Galanin is a 29‐amino‐acid peptide expressed in dorsal root ganglion (DRG) neurones and
spinal dorsal horn neurones. It affects pain threshold and has developmental and trophic …
spinal dorsal horn neurones. It affects pain threshold and has developmental and trophic …
Endogenous galanin potentiates spinal nociceptive processing following inflammation
We have undertaken a series of experiments using galanin null mutant mice to better define
the role of endogenous galanin in spinal excitability following inflammation and in response …
the role of endogenous galanin in spinal excitability following inflammation and in response …
Galanin knockout mice reveal nociceptive deficits following peripheral nerve injury
BJ Kerr, WBJ Cafferty, YIK Gupta… - European Journal of …, 2000 - Wiley Online Library
The neuropeptide galanin has been identified as a potential neurotransmitter/
neuromodulator within the central nervous system. In the present study, the role of …
neuromodulator within the central nervous system. In the present study, the role of …
Galanin in sensory neurons in the spinal cord.
Z Wiesenfeld-Hallin, T Bartfai… - Frontiers in …, 1992 - europepmc.org
The distribution and physiological effects of the neuropeptide galanin (GAL) have been
examined in the somatosensory system. GAL is normally present in a few sensory neurons …
examined in the somatosensory system. GAL is normally present in a few sensory neurons …
Mice deficient for galanin receptor 2 have decreased neurite outgrowth from adult sensory neurons and impaired pain‐like behaviour
SA Hobson, FE Holmes, NCH Kerr… - Journal of …, 2006 - Wiley Online Library
Expression of the neuropeptide galanin is markedly up‐regulated within the adult dorsal root
ganglia (DRG) following peripheral nerve injury. We have previously demonstrated that …
ganglia (DRG) following peripheral nerve injury. We have previously demonstrated that …