Quantification of Dynamic [18F]FDG Pet Studies in Acute Lung Injury

E Grecchi, M Veronese, RM Moresco, G Bellani… - Molecular imaging and …, 2016 - Springer
Purpose This work aims to investigate lung glucose metabolism using 2-deoxy-2-[18 F]
fluoro-d-glucose ([18 F] FDG) positron emission tomography (PET) imaging in acute lung …

Molecular imaging of inflammation with PET in acute and ventilator-induced lung injury

G Musch - Frontiers in Physiology, 2023 - frontiersin.org
This review focuses on methods to image acute lung inflammation with Positron Emission
Tomography (PET). Four approaches are discussed that differ for biologic function of the …

Modeling 18F-FDG Kinetics during Acute Lung Injury: Experimental Data and Estimation Errors

AS Dittrich, T Winkler, T Wellman, N de Prost… - PLoS …, 2012 - journals.plos.org
Background There is increasing interest in Positron Emission Tomography (PET) of 2-deoxy-
2-[18F] flouro-D-glucose (18F-FDG) to evaluate pulmonary inflammation during acute lung …

[18F]Fluorodeoxyglucose Positron Emission Tomography for Lung Antiinflammatory Response Evaluation

DL Chen, TJ Bedient, J Kozlowski… - American journal of …, 2009 - atsjournals.org
Rationale: Few noninvasive biomarkers for pulmonary inflammation are currently available
that can assess the lung-specific response to antiinflammatory treatments. Positron emission …

Early inflammation mainly affects normally and poorly aerated lung in experimental ventilator-induced lung injury

JB Borges, ELV Costa, F Suarez-Sipmann… - Critical care …, 2014 - journals.lww.com
Objective: The common denominator in most forms of ventilator-induced lung injury is an
intense inflammatory response mediated by neutrophils. PET with [18 F] fluoro-2-deoxy-D …

FDG‐PET quantification of lung inflammation with image‐derived blood input function in mice

LW Locke, MB Williams, KD Fairchild… - … journal of molecular …, 2011 - Wiley Online Library
Dynamic FDG‐PET imaging was used to study inflammation in lungs of mice following
administration of a virulent strain of Klebsiella (K.) pneumoniae. Net whole‐lung FDG influx …

18F-FDG kinetics parameters depend on the mechanism of injury in early experimental acute respiratory distress syndrome

N De Prost, Y Feng, T Wellman, MR Tucci… - Journal of Nuclear …, 2014 - Soc Nuclear Med
PET with 18F-FDG allows for noninvasive assessment of regional lung metabolism reflective
of neutrophilic inflammation. This study aimed at determining during early acute lung injury …

Lungs of patients with acute respiratory distress syndrome show diffuse inflammation in normally aerated regions: a [18F]-fluoro-2-deoxy-D-glucose PET/CT study

G Bellani, C Messa, L Guerra, E Spagnolli… - Critical care …, 2009 - journals.lww.com
Objective: Neutrophilic inflammation plays a key role in the pathogenesis of acute
respiratory distress syndrome (ARDS) and acute lung injury (ALI). Positron emission …

Pulmonary cellular dysfunction in endotoxin shock: metabolic and transport derangements.

MM Sayeed - Circulatory Shock, 1982 - europepmc.org
Lung cell metabolic and ion transport alterations in endotoxin shock have been studied to
elucidate mechanisms of endotoxin-induced pulmonary dysfunction. Glucose oxidation to …

Positron emission tomography in the quantification of cellular and biochemical responses to intrapulmonary particulates

HA Jones, K Hamacher, JC Clark, JB Schofield… - Toxicology and applied …, 2005 - Elsevier
Inhaled mineral dusts and fibres can cause chronic pulmonary inflammation, often leading to
permanent scarring with loss of function, but the mechanisms involved remain obscure …