Computational and analytical challenges in single-cell transcriptomics
The development of high-throughput RNA sequencing (RNA-seq) at the single-cell level has
already led to profound new discoveries in biology, ranging from the identification of novel …
already led to profound new discoveries in biology, ranging from the identification of novel …
Cerebro: interactive visualization of scRNA-seq data
R Hillje, PG Pelicci, L Luzi - Bioinformatics, 2020 - academic.oup.com
Despite the growing availability of sophisticated bioinformatic methods for the analysis of
single-cell RNA-seq data, few tools exist that allow biologists without extensive bioinformatic …
single-cell RNA-seq data, few tools exist that allow biologists without extensive bioinformatic …
SigEMD: A powerful method for differential gene expression analysis in single-cell RNA sequencing data
T Wang, S Nabavi - Methods, 2018 - Elsevier
Differential gene expression analysis is one of the significant efforts in single cell RNA
sequencing (scRNAseq) analysis to discover the specific changes in expression levels of …
sequencing (scRNAseq) analysis to discover the specific changes in expression levels of …
Multiplexed single-cell RNA-seq via transient barcoding for simultaneous expression profiling of various drug perturbations
The development of high-throughput single-cell RNA sequencing (scRNA-seq) has enabled
access to information about gene expression in individual cells and insights into new …
access to information about gene expression in individual cells and insights into new …
Batch effects in single-cell RNA-sequencing data are corrected by matching mutual nearest neighbors
Large-scale single-cell RNA sequencing (scRNA-seq) data sets that are produced in
different laboratories and at different times contain batch effects that may compromise the …
different laboratories and at different times contain batch effects that may compromise the …
Machine learning and statistical methods for clustering single-cell RNA-sequencing data
R Petegrosso, Z Li, R Kuang - Briefings in bioinformatics, 2020 - academic.oup.com
Single-cell RNAsequencing (scRNA-seq) technologies have enabled the large-scale whole-
transcriptome profiling of each individual single cell in a cell population. A core analysis of …
transcriptome profiling of each individual single cell in a cell population. A core analysis of …
Systematic comparative analysis of single cell RNA-sequencing methods
J Ding, X Adiconis, SK Simmons, MS Kowalczyk… - BioRxiv, 2019 - biorxiv.org
ABSTRACT A multitude of single-cell RNA sequencing methods have been developed in
recent years, with dramatic advances in scale and power, and enabling major discoveries …
recent years, with dramatic advances in scale and power, and enabling major discoveries …
How to design a single-cell RNA-sequencing experiment: pitfalls, challenges and perspectives
A Dal Molin, B Di Camillo - Briefings in bioinformatics, 2019 - academic.oup.com
The sequencing of the transcriptome of single cells, or single-cell RNA-sequencing, has now
become the dominant technology for the identification of novel cell types in heterogeneous …
become the dominant technology for the identification of novel cell types in heterogeneous …
Computational approaches for interpreting sc RNA‐seq data
R Rostom, V Svensson, SA Teichmann, G Kar - FEBS letters, 2017 - Wiley Online Library
The recent developments in high‐throughput single‐cell RNA sequencing technology (sc
RNA‐seq) have enabled the generation of vast amounts of transcriptomic data at cellular …
RNA‐seq) have enabled the generation of vast amounts of transcriptomic data at cellular …
[HTML][HTML] Comparison and evaluation of statistical error models for scRNA-seq
S Choudhary, R Satija - Genome biology, 2022 - Springer
Background Heterogeneity in single-cell RNA-seq (scRNA-seq) data is driven by multiple
sources, including biological variation in cellular state as well as technical variation …
sources, including biological variation in cellular state as well as technical variation …