Recently a cDNA clone, vanilloid receptor subtype-1 (VR1), was isolated and found to
encode an ion channel that is activated by both capsaicin, the pain producing compound in …

抄録 Capsaicin, the main pungent ingredient in 'hot'chili peppers, elicits burning pain by
activating specific (vanilloid) receptors on sensory nerve endings. The cloned capsaicin …

Capsaicin, the main pungent ingredient in" hot" chili peppers, elicits burning pain by
activating specific (vanilloid) receptors on sensory nerve endings. The cloned vanilloid …

Capsaicin ion channels are highly expressed in peripheral nervous terminals and involved
in pain and thermal sensations. One characteristic of the cloned VR1 receptor is its …

The capsaicin (vanilloid) receptor, VR1, is a sensory neuron-specific ion channel that serves
as a polymodal detector of pain-producing chemical and physical stimuli. The response of …

The recently cloned vanilloid receptor subtype 1 (VR1) is a ligand-gated channel that is
activated by capsaicin, protons, and heat. We have attempted to develop a dominant …

The recently cloned rat vanilloid receptor, VR1, can be activated by capsaicin, acid, and
heat. To determine the molecular mechanisms facilitating channel opening in response to …

Capsaicin, resiniferatoxin, protons or heat have been shown to activate an ion channel,
termed the rat vanilloid receptor-1 (rVR1), originally isolated by expression cloning for a …

A vanilloid receptor (VR1) has recently been cloned and shown to be a target for capsaicin,
the excitotoxic component of capsicum peppers (Caterina, MJ, Schumacher, MA, Tominaga …

▪ Abstract The detection of painful stimuli occurs primarily at the peripheral terminals of
specialized sensory neurons called nociceptors. These small-diameter neurons transduce …