Effect of nitric oxide synthase inhibition on the cerebral vascular response to hypercapnia in primates

RW McPherson, JR Kirsch, RF Ghaly, RJ Traystman - Stroke, 1995 - Am Heart Assoc
Background and Purpose The role of nitric oxide in cerebrovascular response to changes in
Pco2 is unclear. In the present study, we assessed responses at two levels of hypercapnia in …

Widespread attenuation of the cerebrovascular reactivity to hypercapnia following inhibition of nitric oxide synthase in the conscious rat

G Bonvento, J Seylaz… - Journal of Cerebral Blood …, 1994 - journals.sagepub.com
Despite the increasing number of publications devoted to the cerebrovascular role of NO, its
precise influence in awake animals is still poorly characterized. The effect of nitric oxide …

Nitric oxide synthase inhibition in humans reduces cerebral blood flow but not the hyperemic response to hypercapnia

RP White, C Deane, P Vallance, HS Markus - Stroke, 1998 - Am Heart Assoc
Background and Purpose—Animal studies suggest that nitric oxide (NO) is important in
basal cerebral blood flow (CBF) regulation and that it may mediate the vasodilatory …

Nitric oxide-dependent and-independent components of cerebrovasodilation elicited by hypercapnia

C Iadecola, F Zhang - American Journal of Physiology …, 1994 - journals.physiology.org
We studied the effect of nitro-L-arginine methyl ester (L-NAME), a nitric oxide synthase
(NOS) inhibitor, on the increases in cerebral blood flow (CBF) elicited by stepwise elevations …

Neuronal NOS-derived NO plays permissive role in cerebral blood flow response to hypercapnia

H Okamoto, AG Hudetz, RJ Roman… - American Journal …, 1997 - journals.physiology.org
The aim of the present study was to determine whether neuronal nitric oxide synthase
(nNOS)-derived nitric oxide (NO) plays a permissive role in the regulation of cerebral blood …

Nitric oxide synthesis and regional cerebral blood flow responses to hypercapnia and hypoxia in the rat

DA Pelligrino, HM Koenig… - Journal of Cerebral …, 1993 - journals.sagepub.com
The role of nitric oxide (NO) synthesis in the cerebral hyperemic responses to hypercapnia
and hypoxia was investigated in anesthetized rats. Regional CBF (rCBF) measurements …

Role of nitric oxide in the regulation of cerebral blood flow in humans: chemoregulation versus mechanoregulation

S Lavi, R Egbarya, R Lavi, G Jacob - Circulation, 2003 - Am Heart Assoc
Background—From animal studies it emerged that nitric oxide is important for the
modulation of CO2-mediated cerebral blood flow (CBF chemoregulation) but not for the …

Effect of Nitric Oxide Blockade by NG-Nitro-l-Arginine on Cerebral Blood Flow Response to Changes in Carbon Dioxide Tension

Q Wang, OB Paulson… - Journal of Cerebral Blood …, 1992 - journals.sagepub.com
The importance of nitric oxide (NO) for CBF variations associated with arterial carbon
dioxide changes was investigated in halothane-anesthetized rats by using an inhibitor of …

Role of nitric oxide in regulating cerebrocortical oxygen consumption and blood flow during hypercapnia

I Horvath, NT Sandor, Z Ruttner… - Journal of Cerebral …, 1994 - journals.sagepub.com
The effect of the nitric oxide (NO) synthase inhibitor N ω-nitro-l-arginine methyl ester (l-
NAME) on the response of cerebrocortical oxygen consumption (CMRO2) and blood flow …

Nitric oxide and prostaglandin pathways interact in the regulation of hypercapnic cerebral vasodilatation

Heinert, Nye, Paterson - Acta physiologica scandinavica, 1999 - Wiley Online Library
To test whether nitric oxide and prostaglandin pathways interact in hypercapnic cerebral
vasodilatation, cerebral blood flow (CBF) was measured in enflurane anaesthetized …