Three series of novel quinazoline and pyrido [2, 3-d] pyrimidine derivatives were designed,
synthesized and evaluated for their ability to inhibit EGFR tyrosine kinase and a panel of five …

In the present investigation, we employed pyrrolo [2, 3-d] pyrimidine, potassium amide, and
liquid ammonia to synthesize pyrrolo [2, 3-d] pyrimidin-2-amine derivatives (4a-n) …

Herein, we synthesized some new fused [1, 2, 3] triazolo-pyrrolo [1, 2-a] pyrido [4, 3-d]
pyrimidines via click chemistry followed by carbon-carbon bond coupling as key approach …

A series of novel hybrid pyrazolo [3, 4-d] pyramidine derivatives was designed and
chemically synthesized in useful yields. The synthesized compounds were structurally …

Eight series of quinazoline derivatives bearing 2, 3-dihydro-indole or 1, 2, 3, 4-
tetrahydroquinoline were designed, synthesized and evaluated for the IC 50 values against …

Quinolines have a weighty effect as anticancer agents and 1, 4‐DHPs have demonstrated
efficacy as anticancer agents in several studies, as well. New hybrid models of symmetric …

Background: Several pyrazolo [3, 4-d] pyrimidine derivatives have been reported as anti-
cancer agents via acting as EGFR inhibitors, mammalian target of rapamycin (mTOR) …

Abstract A series of novel 6, 7-dimorpholinoalkoxy quinazoline derivatives was designed,
synthesized and evaluated as potent EGFR inhibitors. Most of synthesized derivatives …

We report a series of hybrid quinazoline‐1, 3, 5‐triazine derivatives as EGFR inhibitors,
which were synthesised and tested by using a variety of in vitro, in silico, and in vivo …

Epidermal growth factor receptor (EGFR) enhances lung cancer development, due to their
inability to permeate the cell membrane, secreted growth factors work through specialized …