Early identification of sepsis and septic shock, along with its aggressive goal directed
therapy, is proven to improve outcomes in paediatric patients. 1 The American College of …

To the Editor Scott et al1 reported on 1299 children evaluated for suspected sepsis at a
tertiary emergency department. They observed a 3-fold increase in 30-day mortality in …

To the Editor Scott et al1 reported on 1299 children evaluated for suspected sepsis at a
tertiary emergency department. They observed a 3-fold increase in 30-day mortality in …

Importance Improving emergency care of pediatric sepsis is a public health priority, but
optimal early diagnostic approaches are unclear. Measurement of lactate levels is …

We write to raise awareness of common themes from paediatric death/incidents of harm from
a network perspective. The governance group within Thames Valley & Wessex Paediatric …

Study Objectives Elevated levels of lactate have been shown to prognosticate outcome in
adult sepsis. The objective of this study is to determine whether lactate can reliably identify …

Objectives Failure to recognize shock contributes to inadequate early resuscitation in many
children with sepsis. Serum lactate levels are used to identify adult patients with septic …

Objectives Current guidelines emphasize early recognition of pediatric septic shock using
clinical examination findings. Elevated serum lactate has been associated with increased …

Objectives To evaluate whether lactate clearance and normalization during emergency care
of pediatric sepsis is associated with lower rates of persistent organ dysfunction. Study …

Blood lactate has become easy to measure, with results now readily available to us in
clinical practice from point-of-care testing and blood gas analysers. It has long been …