Phytochemicals as immunomodulatory molecules in cancer therapeutics
Phytochemicals are natural plant-derived products that provide significant nutrition, essential
biomolecules, and flavor as part of our diet. They have long been known to confer protection …
biomolecules, and flavor as part of our diet. They have long been known to confer protection …
Role of therapeutic agents on repolarisation of tumour-associated macrophage to halt lung cancer progression
HM Aldawsari, B Gorain, NA Alhakamy… - Journal of Drug …, 2020 - Taylor & Francis
Tumour-associated macrophages (TAMs) represent as much as 50% of the solid mass in
different types of human solid tumours including lung, breast, ovarian and pancreatic …
different types of human solid tumours including lung, breast, ovarian and pancreatic …
Lipid accumulation in macrophages confers protumorigenic polarization and immunity in gastric cancer
Q Luo, N Zheng, L Jiang, T Wang, P Zhang… - Cancer …, 2020 - Wiley Online Library
Heterotypic interactions between tumor cells and macrophages can enable tumor
progression and hold potential for the development of therapeutic interventions. However …
progression and hold potential for the development of therapeutic interventions. However …
[HTML][HTML] Metabolic influence on macrophage polarization and pathogenesis
B Thapa, K Lee - BMB reports, 2019 - ncbi.nlm.nih.gov
Macrophages play an essential role not only in mediating the first line of defense but also in
maintaining tissue homeostasis. In response to extrinsic factors derived from a given tissue …
maintaining tissue homeostasis. In response to extrinsic factors derived from a given tissue …
Mechanisms of macrophage plasticity in the tumor environment: manipulating activation state to improve outcomes
TD Ricketts, N Prieto-Dominguez, PS Gowda… - Frontiers in …, 2021 - frontiersin.org
Macrophages are a specialized class of innate immune cells with multifaceted roles in
modulation of the inflammatory response, homeostasis, and wound healing. While …
modulation of the inflammatory response, homeostasis, and wound healing. While …
LZ205, a newly synthesized flavonoid compound, exerts anti-inflammatory effect by inhibiting M1 macrophage polarization through regulating PI3K/AKT/mTOR …
D Bai, Y Zhao, Q Zhu, Y Zhou, Y Zhao, T Zhang… - Experimental cell …, 2018 - Elsevier
Macrophage polarization is involved in the process of inflammation. Regulation of
macrophage polarization is considered to be an effective method for the treatment of various …
macrophage polarization is considered to be an effective method for the treatment of various …
Immunomodulatory functional foods and their molecular mechanisms
JH Kim, DH Kim, S Jo, MJ Cho, YR Cho… - … & Molecular Medicine, 2022 - nature.com
The immune system comprises a complex group of processes that provide defense against
diverse pathogens. These defenses can be divided into innate and adaptive immunity, in …
diverse pathogens. These defenses can be divided into innate and adaptive immunity, in …
2-Deoxy-d-Glucose Treatment Decreases Anti-inflammatory M2 Macrophage Polarization in Mice with Tumor and Allergic Airway Inflammation
Q Zhao, Z Chu, L Zhu, T Yang, P Wang, F Liu… - Frontiers in …, 2017 - frontiersin.org
As important effector cells in inflammation, macrophages can be functionally polarized into
either inflammatory M1 or alternatively activated anti-inflammatory M2 phenotype depending …
either inflammatory M1 or alternatively activated anti-inflammatory M2 phenotype depending …
Chemopreventive agents targeting tumor microenvironment
SH Sharma, S Thulasingam, S Nagarajan - Life sciences, 2016 - Elsevier
Recent studies have shown that tumor development and progression depend not only on
the perturbed genes that govern cell proliferation, but is also highly determined by the non …
the perturbed genes that govern cell proliferation, but is also highly determined by the non …
Ethanol Extract of Mylabris phalerata Inhibits M2 Polarization Induced by Recombinant IL‐4 and IL‐13 in Murine Macrophages
HS Chung, BS Lee, JY Ma - Evidence‐Based Complementary …, 2017 - Wiley Online Library
Mylabris phalerata (MP) is an insect used in oriental herbal treatments for tumor, tinea
infections, and stroke. Recent studies have shown that tumor‐associated macrophages …
infections, and stroke. Recent studies have shown that tumor‐associated macrophages …