In recent years, the strategy for tumor therapy has changed from focusing on the direct killing
effect of different types of therapeutic agents on cancer cells to the new mainstream of multi …

Macrophages are present in most human tissues and have very diverse functions. Activated
macrophages are usually divided into two phenotypes, M1 macrophages and M2 …

Macrophages undergo activation by pathophysiological stimuli to pro-inflammatory and
bactericidal, or wound-healing and anti-inflammatory phenotypes, termed M1 or M2 …

Macrophages are a well recognized player of both innate and adaptive immunity and have
emerged as a key regulator of systemicmetabolism, hematopoiesis, vasculogenesis …

Background: Tumor environment has been recognized to affect cancer cell progression,
such as tumor-associated macrophages. However, increasing evidences suggest that tumor …

Macrophage polarization has been well documented. Macrophages can aquire two
phenotypes, the pro-inflammatory M1 phenotype, and the anti-inflammatory and wound …

Background Obesity leads to the chronic inflammation in the whole body and triggers the
macrophage polarization to the pro-inflammatory phenotype. Targeting macrophage …

Rather than primary solid tumors, metastasis is one of the hallmarks of most cancer deaths.
Metastasis is a multistage event in which cancer cells escape from the primary tumor survive …

Macrophages display remarkable plasticity and can possess distinct functions in response to
different environmental stimuli. Classically activated macrophages (M1 macrophages) are …

Macrophages are potent immune effector cells in innate immunity and exert dual-effects in
the tumor microenvironment (TME). Tumor-associated macrophages (TAMs) make up a …