Eicosapentaenoic acid and docosahexaenoic acid inhibit macrophage-induced gastric cancer cell migration by attenuating the expression of matrix metalloproteinase …

MH Wu, YT Tsai, KT Hua, KC Chang, ML Kuo… - The Journal of nutritional …, 2012 - Elsevier
Uptake of docosahexaenoic acid (DHA)/eicosapentaenoic acid (EPA) improves the
treatment of cancer and reduces tumor-associated macrophage count. However, the …

[PDF][PDF] In vitro macrophage activation: A technique for screening anti-inflammatory, immunomodulatory and anticancer activity of phytomolecules

PH Paradkar, LS Mishra, JV Joshi, SP Dandekar… - 2017 - researchgate.net
Macrophage activation plays a significant role in homeostasis of organisms. Various internal
and external stress factors may affect their function, leading to adverse effects on the body.'In …

Arachidonic acid metabolism controls macrophage alternative activation through regulating oxidative phosphorylation in PPARγ dependent manner

M Xu, X Wang, Y Li, X Geng, X Jia, L Zhang… - Frontiers in …, 2021 - frontiersin.org
Macrophage polarization is mainly steered by metabolic reprogramming in the tissue
microenvironment, thus leading to distinct outcomes of various diseases. However, the role …

[HTML][HTML] Targeting macrophage polarization for reinstating homeostasis following tissue damage

Q Du, A Dickinson, P Nakuleswaran… - International Journal of …, 2024 - mdpi.com
Tissue regeneration and remodeling involve many complex stages. Macrophages are
critical in maintaining micro-environmental homeostasis by regulating inflammation and …

Lactic acid in alternative polarization and function of macrophages in tumor microenvironment

KK Goswami, S Banerjee, A Bose, R Baral - Human immunology, 2022 - Elsevier
In developing tumor, macrophages are one major immune infiltrate that not only contributes
in shaping up of tumor microenvironment (TME) but also have the potential of determining …

Screening five qi‐tonifying herbs on M2 phenotype macrophages

YX Jiang, Y Chen, Y Yang, XX Chen… - Evidence‐Based …, 2019 - Wiley Online Library
Tumor‐associated macrophages (TAMs) with M2 phenotype play an essential role in tumor
microenvironment (TME) during the progression and development of numerous cancers and …

Roles for macrophage-polarizing interleukins in cancer immunity and immunotherapy

K Mortezaee, J Majidpoor - Cellular Oncology, 2022 - Springer
Macrophages are the most abundant and one of the most critical cells of tumor immunity.
They provide a bridge between innate and adaptive immunity through releasing cytokines …

Targeting macrophage metabolism to enhance tumor immunotherapy

J Liu, Z Ma, W Jia, P Lan - Cellular & Molecular Immunology, 2024 - nature.com
Tumor-associated macrophages (TAMs) are important components of the tumor
microenvironment (TME) and are characterized by plasticity and heterogeneity. This …

Pyropia yezoensis glycoprotein promotes the M1 to M2 macrophage phenotypic switch via the STAT3 and STAT6 transcription factors

JW Choi, MJ Kwon, IH Kim… - International …, 2016 - spandidos-publications.com
Macrophage polarization has been well documented. Macrophages can aquire two
phenotypes, the pro-inflammatory M1 phenotype, and the anti-inflammatory and wound …

Macrophage polarization in tumour progression

A Sica, P Larghi, A Mancino, L Rubino, C Porta… - Seminars in cancer …, 2008 - Elsevier
Macrophages are a fundamental part of the innate defense mechanisms, which can promote
specific immunity by inducing T cell recruitment and activation. Despite this, their presence …