Low toxicity and excellent outcomes in patients with DLBCL without residual lymphoma at the time of CD19 CAR T-cell therapy

K Wudhikarn, AA Tomas, JR Flynn, SM Devlin… - Blood …, 2023 - ashpublications.org
CD19 chimeric antigen receptor (CAR) T-cell therapy represents a breakthrough for patients
with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL), inducing sustained …

The role of CAR-T cell therapy as second line in diffuse large B-cell lymphoma

O Albanyan, J Chavez, J Munoz - Therapeutic advances in …, 2022 - journals.sagepub.com
For approximately three decades, autologous hematopoietic cell transplantation (auto-HCT)
has been the standard of care for patients with relapsed/refractory (R/R) diffuse large B-cell …

[HTML][HTML] Salvage radiotherapy in relapsed/refractory large B-cell lymphoma after failure of CAR T-cell therapy

HS Ababneh, AK Ng, MJ Frigault, JS Abramson… - …, 2023 - ncbi.nlm.nih.gov
Despite the success of CD19-targeted chimeric antigen receptor (CAR T)-cell therapy in
patients with relapsed/refractory large B-cell lymphoma (LBCL), there is a need for effective …

Outcomes in patients with DLBCL treated with commercial CAR T cells compared with alternate therapies

D Sermer, C Batlevi, ML Palomba, G Shah… - Blood …, 2020 - ashpublications.org
The prognosis of patients with relapsed or refractory (R/R) diffuse large B-cell lymphoma
(DLBCL) is poor. Chimeric antigen receptor (CAR) T-cell therapy has been approved for R/R …

CD19 CAR-T expressing PD-1/CD28 chimeric switch receptor as a salvage therapy for DLBCL patients treated with different CD19-directed CAR T-cell therapies

Y Liang, H Liu, Z Lu, W Lei, C Zhang, P Li… - Journal of Hematology & …, 2021 - Springer
CD19-targeted chimeric antigen receptor T (CAR T) cell therapy is a promising option to
treat relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL). However, the majority …

CD22-directed CAR T-cell therapy induces complete remissions in CD19-directed CAR–refractory large B-cell lymphoma

JH Baird, MJ Frank, J Craig, S Patel… - Blood, The Journal …, 2021 - ashpublications.org
The prognosis of patients with large B-cell lymphoma (LBCL) that progresses after treatment
with chimeric antigen receptor (CAR) T-cell therapy targeting CD19 (CAR19) is poor. We …

[HTML][HTML] Overcoming barriers to referral for chimeric antigen receptor T cell therapy in patients with relapsed/refractory diffuse large B cell lymphoma

MS Hoffmann, BD Hunter, PW Cobb, JC Varela… - … and Cellular Therapy, 2023 - Elsevier
Diffuse large B cell lymphoma (DLBCL) is the most prevalent subtype of non-Hodgkin
lymphoma. Although outcomes to frontline therapy are encouraging, patients who are …

[HTML][HTML] MSKCC early experience using radiotherapy as a bridging strategy for relapsed diffuse large B cell lymphoma before CD19 CAR T therapy

B Imber, ML Palomba, C DeSelm, CL Batlevi, PB Dahi… - Blood, 2019 - Elsevier
Background: CD19-targeted chimeric antigen receptor T cell (CAR T) therapies have
remarkable overall response rates (ORR) for relapsed diffuse large B cell lymphoma …

Autologous CD19-directed chimeric antigen receptor-T cell is an effective and safe treatment to refractory or relapsed diffuse large B-cell lymphoma

F Bao, W Wan, T He, F Qi, G Liu, K Hu, X Lu… - Cancer gene …, 2019 - nature.com
Patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) have a poor
prognosis. Chimeric antigen receptor (CAR) modified T cells targeting CD19 hold great …

Dual targeting of CD19 and CD22 with bicistronic CAR-T cells in patients with relapsed/refractory large B-cell lymphoma

C Roddie, LJ Lekakis, MAV Marzolini… - Blood, The Journal …, 2023 - ashpublications.org
Relapse after CD19-directed chimeric antigen receptor T-cell (CAR-T) therapy for large B-
cell lymphoma (LBCL) is commonly ascribed to antigen loss or CAR-T exhaustion …