Identification of a novel IL-5 signaling pathway in chronic pancreatitis and crosstalk with pancreatic tumor cells
Background While inflammation is associated with pancreatic cancer, the underlying
mechanisms leading to cancer initiation are still being delineated. Eosinophils may promote …
mechanisms leading to cancer initiation are still being delineated. Eosinophils may promote …
[HTML][HTML] Interleukin 22 signaling regulates acinar cell plasticity to promote pancreatic tumor development in mice
Background & Aims Pancreatic ductal adenocarcinoma (PDAC) is an aggressive
malignancy that invades surrounding structures and metastasizes rapidly. Although …
malignancy that invades surrounding structures and metastasizes rapidly. Although …
IL22RA1/STAT3 signaling promotes stemness and tumorigenicity in pancreatic cancer
Chronic inflammation is a feature of pancreatic cancer, but little is known about how immune
cells or immune cell–related signals affect pancreatic cancer stemness and development …
cells or immune cell–related signals affect pancreatic cancer stemness and development …
Interleukin-6 is required for pancreatic cancer progression by promoting MAPK signaling activation and oxidative stress resistance
Pancreatic cancer, one of the deadliest human malignancies, is almost invariably associated
with the presence of an oncogenic form of Kras. Mice expressing oncogenic Kras in the …
with the presence of an oncogenic form of Kras. Mice expressing oncogenic Kras in the …
Differential role of Interleukin-1 and Interleukin-6 in K-Ras-driven pancreatic carcinoma undergoing mesenchymal transition
I Siddiqui, M Erreni, MA Kamal, C Porta… - …, 2018 - Taylor & Francis
ABSTRACT K-Ras mutations are a hallmark of human pancreatic adenocarcinoma (PDAC)
and epithelial-mesenchymal-transition (EMT) is a driver of progression. Oncogenic K-Ras …
and epithelial-mesenchymal-transition (EMT) is a driver of progression. Oncogenic K-Ras …
Interleukin-6: a villain in the drama of pancreatic cancer development and progression
R Holmer, FA Goumas, GH Waetzig… - … & Pancreatic Diseases …, 2014 - Elsevier
Background Pancreatic ductal adenocarcinoma (PDAC) is a devastating malignancy with a
poor prognosis and little treatment options. The development and progression of the disease …
poor prognosis and little treatment options. The development and progression of the disease …
Emerging roles for the IL-6 family of cytokines in pancreatic cancer
G van Duijneveldt, MDW Griffin, TL Putoczki - Clinical science, 2020 - portlandpress.com
Pancreatic cancer has one of the poorest prognoses of all malignancies, with little
improvement in clinical outcome over the past 40 years. Pancreatic ductal adenocarcinoma …
improvement in clinical outcome over the past 40 years. Pancreatic ductal adenocarcinoma …
IL-6 stimulates Th2 type cytokine secretion and upregulates VEGF and NRP-1 expression in pancreatic cancer cells
LW Feurino, Y Zhang, U Bharadwaj… - Cancer biology & …, 2007 - Taylor & Francis
BACKGROUND. Although upregulation of interleukin-6 (IL-6) is associated with many solid
tumors, its role in pancreatic cancer has not been well elucidated. In this study, we examined …
tumors, its role in pancreatic cancer has not been well elucidated. In this study, we examined …
The presence of interleukin-13 at pancreatic ADM/PanIN lesions alters macrophage populations and mediates pancreatic tumorigenesis
The contributions of the innate immune system to the development of pancreatic cancer are
still ill defined. Inflammatory macrophages can initiate metaplasia of pancreatic acinar cells …
still ill defined. Inflammatory macrophages can initiate metaplasia of pancreatic acinar cells …
Blocking IL-6/GP130 signaling inhibits cell viability/proliferation, glycolysis, and colony forming activity in human pancreatic cancer cells
Background: Elevated production of the pro-inflammatory cytokine interleukin-6 (IL-6) and
dysfunction of IL-6 signaling promotes tumorigenesis and are associated with poor survival …
dysfunction of IL-6 signaling promotes tumorigenesis and are associated with poor survival …