Evaluation of riboflavin transporters as targets for drug delivery and theranostics

L Bartmann, D Schumacher, S Von Stillfried… - Frontiers in …, 2019 - frontiersin.org
The retention and cellular internalization of drug delivery systems and theranostics for
cancer therapy can be improved by targeting molecules. Since an increased uptake of …

Riboflavin-targeted drug delivery

M Darguzyte, N Drude, T Lammers, F Kiessling - Cancers, 2020 - mdpi.com
Active targeting can improve the retention of drugs and drug delivery systems in tumors,
thereby enhancing their therapeutic efficacy. In this context, vitamin receptors that are …

Influence of riboflavin targeting on tumor accumulation and internalization of Peptostar based drug delivery systems

M Darguzyte, R Holm, J Baier, N Drude… - Bioconjugate …, 2020 - ACS Publications
Riboflavin carrier protein (RCP) and riboflavin transporters (RFVTs) have been reported to
be highly overexpressed in various cancer cells. Hence, targeting RCP and RFVTs using …

Balancing passive and active targeting to different tumor compartments using riboflavin-functionalized polymeric nanocarriers

Y Tsvetkova, N Beztsinna, M Baues, D Klein, A Rix… - Nano …, 2017 - ACS Publications
Riboflavin transporters (RFTs) and the riboflavin carrier protein (RCP) are highly
upregulated in many tumor cells, tumor stem cells, and tumor neovasculature, which makes …

[HTML][HTML] Differential expression of human riboflavin transporters-1,-2, and-3 in polarized epithelia: a key role for hRFT-2 in intestinal riboflavin uptake

VS Subramanian, SB Subramanya, L Rapp… - … et Biophysica Acta (BBA …, 2011 - Elsevier
Transport of riboflavin (RF) across both the brush border membrane (BBM) and basolateral
membrane (BLM) of the polarized enterocyte occurs via specific carrier-mediated …

Current perspectives on the cellular uptake and trafficking of riboflavin

AB Foraker, CM Khantwal, PW Swaan - Advanced drug delivery reviews, 2003 - Elsevier
The role of riboflavin in cell maintenance and growth, and the mechanism by which it is
absorbed into various human tissues and cell lines has been extensively studied over the …

Identification and functional characterization of a novel human and rat riboflavin transporter, RFT1

A Yonezawa, S Masuda… - American Journal of …, 2008 - journals.physiology.org
Absorption of riboflavin is mediated by transporter (s). However, a mammalian riboflavin
transporter has yet to be identified. In the present study, the novel human and rat riboflavin …

Amphiphilic phospholipid-based riboflavin derivatives for tumor targeting nanomedicines

N Beztsinna, Y Tsvetkova, M Bartneck… - Bioconjugate …, 2016 - ACS Publications
Riboflavin (RF) is an essential vitamin for cellular metabolism. Recent studies have shown
that RF is internalized through RF transporters, which are highly overexpressed by prostate …

Functional involvement of RFVT3/SLC52A3 in intestinal riboflavin absorption

H Yoshimatsu, A Yonezawa, Y Yao… - American Journal …, 2014 - journals.physiology.org
Riboflavin, also known as vitamin B2, is transported across the biological membrane into
various organs by transport systems. Riboflavin transporter RFVT3 is expressed in the small …

Involvement of endocytic organelles in the subcellular trafficking and localization of riboflavin

SN Huang, MA Phelps, PW Swaan - Journal of Pharmacology and …, 2003 - ASPET
Previous studies by our laboratory have suggested the potential role of receptor-mediated
endocytosis components in the cellular translocation of riboflavin (vitamin B2). To delineate …