We previously described X-ray histotomography, a high-resolution, non-destructive form of X-
ray microtomography (micro-CT) imaging customized for three-dimensional (3D), digital …

Lower vertebrates, including fish, can rapidly alter skin lightness through changes in
melanin concentration and melanosomes' mobility according to various factors, which …

Histological studies providing cellular insights into tissue architecture have been central to
biological discovery and remain clinically invaluable today. Extending histology to three …

Melanocytes are specialized neural crest-derived cells present in the epidermal skin. These
cells synthesize melanin pigment that protects the genome from harmful ultraviolet …

Organismal phenotypes frequently involve multiple organ systems. Histology is a powerful
way to detect cellular and tissue phenotypes, but is largely descriptive and subjective. To …

We are creating a state-of-the-art 2D and 3D imaging atlas of zebrafish development. The
atlas employs both 2D histology slides and 3D benchtop and synchrotron micro CT results …

In developmental and cell biology, understanding the spatial distribution of gene activity
offers new insights into developmental processes within an organism and the underlying …

Zebrafish is now widely used in biomedical research as a model for human diseases, but the
relevance of the model depends on a rigorous analysis of the phenotypes obtained. Many …

Imaging can potentially make a major contribution to the Zebrafish Phenome Project, which
will probe the functions of vertebrate genes through the generation and phenotyping of …

Unveiling mechanisms driving specification, recruitment and regeneration of melanophores
is key in understanding melanin-related disorders. This study reports on the applicability of a …