In Silico-Based Discovery of Natural Anthraquinones with Potential against Multidrug-Resistant E. coli

HA Alhadrami, WH Abdulaal, HM Hassan… - Pharmaceuticals, 2022 - mdpi.com
E. coli is a Gram-negative bacterium that causes different human infections. Additionally, it
resists common antibiotics due to its outer protective membrane. Natural products have …

Chrysoxanthones A–C, Three New Xanthone–Chromanone Heterdimers from Sponge-Associated Penicillium chrysogenum HLS111 Treated with Histone …

X Zhen, T Gong, YH Wen, DJ Yan, JJ Chen, P Zhu - Marine drugs, 2018 - mdpi.com
By treating with histone-deacetylase inhibitor valproate sodium, three new heterdimeric
tetrahydroxanthone–chromanone lactones chrysoxanthones A–C (1–3), along with 17 …

Isolation, structure elucidation, and biological evaluation of the unusual heterodimer chrysoxanthone from the ascomycete IBWF11-95A

A Schüffler, JC Liermann, H Kolshorn, T Opatz… - Tetrahedron Letters, 2009 - Elsevier
Chrysoxanthone, an unusual heterodimer of blennolide A and 2-hydroxychrysophanol
linked through a diaryl ether bridge, was isolated from mycelia of the ascomycete IBWF11 …

Synthesis and evaluation of antitumour activity in vitro and in vivo of chrysin salicylate derivatives

X Deng, Z Zhao, S Xiong, R Xiong, J Liu… - Natural product …, 2018 - Taylor & Francis
A series of chrysin salicylate derivatives as potential antitumour agents were synthesised
and evaluated their antitumour activities in vitro and in vivo. Most of the compounds …

Analysis of metabolites of anthraquinones by human fecal bacteria using UPLC-Q-TOF-HRMS/MS

M Fan, C Peng, Y Peng, M Zhang, X Li - Chromatographia, 2016 - Springer
This study aimed to investigate the metabolism of anthraquinones, including chrysophanol
(1), rhein (2), aloe-emodin (3), emodin (4), sennoside A (5) and sennoside B (6), by mixed …

Synthesis of chrysin derivatives and screening of antitumor activity

N Chen, R Wang, LJ Lu, LJ Yan, LL Bai… - Journal of Asian …, 2020 - Taylor & Francis
A series of aromatic or long-chain chrysin derivatives (1–10) were synthesized by
esterification of chrysin and acyl chloride. The chemical structures of these compounds were …

Design, synthesis, and biological evaluation of chrysin derivatives as potential FabH inhibitors

HX Li, ZC Wang, YM Qian, XQ Yan… - Chemical Biology & …, 2017 - Wiley Online Library
New series of chrysin derivatives (4a–4t) were designed and synthesized by introducing
different substituted piperazines at C‐7 position. Their inhibitory effects on FabH were …

Antibacterial activities of plant-derived xanthones

X Liu, J Shen, K Zhu - RSC Medicinal Chemistry, 2022 - pubs.rsc.org
The increasing threat to global health posed by antibiotic resistance remains a serious
concern. This troublesome scenario has steered a need for the discovery and evaluation of …

Synthesis of a small library of nature-inspired xanthones and study of their antimicrobial activity

DISP Resende, P Pereira-Terra, J Moreira… - Molecules, 2020 - mdpi.com
A series of thirteen xanthones 3–15 was prepared based on substitutional (appendage)
diversity reactions. The series was structurally characterized based on their spectral data …

Identification and Structure Elucidation of a Novel Antifungal Compound Produced by Pseudomonas aeruginosa PGPR2 Against Macrophomina phaseolina

D Illakkiam, P Ponraj, M Shankar… - Applied biochemistry …, 2013 - Springer
Pseudomonas aeruginosa PGPR2 was found to protect mungbean plants from charcoal rot
disease caused by Macrophomina phaseolina. Secondary metabolites from the culture …