Regulation of dopamine transporter function by protein‐protein interactions: new discoveries and methodological challenges

J Eriksen, TN Jørgensen, U Gether - Journal of neurochemistry, 2010 - Wiley Online Library
J. Neurochem.(2010) 10.1111/j. 1471‐4159.2010. 06599. x Abstract The dopamine
transporter (DAT) plays a key role in regulating dopaminergic signalling in the brain by …

The dopamine transporter proteome

GE Torres - Journal of neurochemistry, 2006 - Wiley Online Library
Dopamine (DA) uptake through the neuronal plasma membrane DA transporter (DAT) is
essential for the maintenance of normal DA homeostasis in the brain. The DAT‐mediated re …

Molecular biology, pharmacology and functional role of the plasma membrane dopamine transporter

TD Sotnikova, JM Beaulieu… - CNS & Neurological …, 2006 - ingentaconnect.com
The plasma membrane dopamine transporter (DAT) tightly regulates the extracellular
concentrations of dopamine (DA) by re-capturing released neurotransmitter back into the …

Regulation of the dopamine transporter: aspects relevant to psychostimulant drugs of abuse

KC Schmitt, MEA Reith - Annals of the New York Academy of …, 2010 - Wiley Online Library
Dopaminergic signaling in the brain is primarily modulated by dopamine transporters
(DATs), which actively translocate extraneuronal dopamine back into dopaminergic …

Identification of a novel allosteric modulator of the human dopamine transporter

S Aggarwal, X Liu, C Rice, P Menell… - ACS chemical …, 2019 - ACS Publications
The dopamine transporter (DAT) serves a pivotal role in controlling dopamine (DA)-
mediated neurotransmission by clearing DA from synaptic and perisynaptic spaces and …

[HTML][HTML] Dopamine transporter ligand binding domains: structural and functional properties revealed by limited proteolysis

RA Vaughan, MJ Kuhar - Journal of Biological Chemistry, 1996 - ASBMB
Dopamine transporters (DATs) are members of the Na+-and Cl−-dependent
neurotransmitter and amino acid transporter family predicted by hydrophobicity analysis to …

Dopamine transporter trafficking: rapid response on demand

R Chen, CA Furman, ME Gnegy - Future neurology, 2010 - Taylor & Francis
The dopamine transporter (DAT) is a primary determinant of the concentration of dopamine
in the synapse and is involved in a number of psychiatric and neurological diseases. The …

Substrates dissociate dopamine transporter oligomers

N Chen, MEA Reith - Journal of neurochemistry, 2008 - Wiley Online Library
Substrate‐induced endocytic trafficking of dopamine transporter (DAT) has been observed,
but little is known about the regulation of DAT oligomerization by substrate. The present …

Regulation of the dopamine transporter by phosphorylation

JD Foster, MA Cervinski, BK Gorentla… - Neurotransmitter …, 2006 - Springer
The dopamine transporter (DAT) is a neuronal phosphoprotein and target for psychoactive
drugs that plays a critical role in terminating dopaminergic transmission by reuptake of …

[HTML][HTML] Oligomerization and trafficking of the human dopamine transporter: mutational analysis identifies critical domains important for the functional expression of the …

GE Torres, A Carneiro, K Seamans, C Fiorentini… - Journal of biological …, 2003 - ASBMB
The dopamine transporter (DAT) is a presynaptic plasma membrane protein responsible for
the termination of dopaminergic neurotransmission in the central nervous system. While …