The presence of breast cancer in any first-degree female relative in general nearly doubles
the risk for a proband and the risk gradually increases with the number of affected relatives …

Hereditary factors account for a significant proportion of breast cancer risk. Approximately
20% of hereditary breast cancers are attributable to pathogenic variants in the highly …

Since the localization and discovery of the first high‐risk breast cancer (BC) genes in 1990,
there has been a substantial progress in unravelling its familial component. Increasing …

It has been 10 years since the BRCA1 gene was first identified. During this decade, genetic
testing for breast cancer susceptibility has been incorporated into the practice of oncology. In …

Genetic testing for BRCA mutations is expanding in clinical oncology centers worldwide.
Testing may help target unaffected high-risk women for prevention and/or close surveillance …

Introduction: Heritage is the most important risk factor for breast cancer. About 15–20% of
breast cancer is familial, referring to affected women who have one or more first-or second …

Germ-line mutations in BRCA1 and BRCA2 confer a high risk of developing breast cancer.
They account, however, for only 40% of strongly familial breast cancer cases. Intensive …

Women who inherit a deleterious BRCA1 or BRCA2 mutation face substantially increased
risks of developing breast cancer, which is estimated at 70%. Although annual screening …

Breast cancer is the most common malignancy among females. 5%–10% of breast cancer
cases are hereditary and are caused by pathogenic mutations in the considered reference …

Inherited breast cancer is associated with germline mutations in ten different genes in
pathways critical to genomic integrity. BRCA1 and BRCA2 mutations confer very high risks …