New therapeutic targets in the neurovascular pathway in Alzheimer's disease
BV Zlokovic - Neurotherapeutics, 2008 - Springer
Recent findings indicate that neurovascular dysfunction is an integral part of Alzheimer's
disease (AD). Changes in the vascular system of the brain may significantly contribute to the …
disease (AD). Changes in the vascular system of the brain may significantly contribute to the …
Neurovascular dysfunction in dementia–human cellular models and molecular mechanisms
From the earliest stages of development, when cerebral angiogenesis and neurogenesis
are entwined, to the end of life, the interplay between vascular and neural systems of the …
are entwined, to the end of life, the interplay between vascular and neural systems of the …
Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease
R Deane, BV Zlokovic - Current Alzheimer Research, 2007 - ingentaconnect.com
Cerebrovascular dysfunction contributes to the cognitive decline and dementia in
Alzheimer's disease (AD), and may precede cerebral amyloid angiopathy and brain …
Alzheimer's disease (AD), and may precede cerebral amyloid angiopathy and brain …
[HTML][HTML] Neurovascular dysfunction in vascular dementia, Alzheimer's and atherosclerosis
Efficient blood supply to the brain is of paramount importance to its normal functioning and
improper blood flow can result in potentially devastating neurological consequences …
improper blood flow can result in potentially devastating neurological consequences …
The early contribution of cerebrovascular factors to the pathogenesis of Alzheimer's disease
PM Pimentel‐Coelho, S Rivest - European Journal of …, 2012 - Wiley Online Library
Alzheimer's disease (AD) and cerebrovascular disorders are the leading causes of dementia
in our ageing population. Given that the progression of neuropathological changes in the …
in our ageing population. Given that the progression of neuropathological changes in the …
[HTML][HTML] Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease
AR Nelson, MD Sweeney, AP Sagare… - Biochimica et Biophysica …, 2016 - Elsevier
Vascular insults can initiate a cascade of molecular events leading to neurodegeneration,
cognitive impairment, and dementia. Here, we review the cellular and molecular …
cognitive impairment, and dementia. Here, we review the cellular and molecular …
Neurovascular mechanisms of Alzheimer's neurodegeneration
BV Zlokovic - Trends in neurosciences, 2005 - cell.com
In contrast to traditional neuroncentric views of Alzheimer's disease (AD), recent findings
indicate that neurovascular dysfunction contributes to cognitive decline and …
indicate that neurovascular dysfunction contributes to cognitive decline and …
[HTML][HTML] Vascular contributions to cognitive impairment, clinical Alzheimer's disease, and dementia in older persons
A Kapasi, JA Schneider - Biochimica et Biophysica Acta (BBA)-Molecular …, 2016 - Elsevier
There is growing evidence suggesting that vascular pathologies and dysfunction play a
critical role in cognitive impairment, clinical Alzheimer's disease, and dementia. Vascular …
critical role in cognitive impairment, clinical Alzheimer's disease, and dementia. Vascular …
Neurovascular dysfunction and faulty amyloid β-peptide clearance in Alzheimer disease
AP Sagare, RD Bell… - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Neurovascular dysfunction is an integral part of Alzheimer disease (AD). Changes in the
brain vascular system may contribute in a significant way to the onset and progression of …
brain vascular system may contribute in a significant way to the onset and progression of …
The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia
C Iadecola - Acta neuropathologica, 2010 - Springer
There is increasing evidence that cerebrovascular dysfunction plays a role not only in
vascular causes of cognitive impairment but also in Alzheimer's disease (AD). Vascular risk …
vascular causes of cognitive impairment but also in Alzheimer's disease (AD). Vascular risk …