New therapeutic targets in the neurovascular pathway in Alzheimer's disease

BV Zlokovic - Neurotherapeutics, 2008 - Springer
Recent findings indicate that neurovascular dysfunction is an integral part of Alzheimer's
disease (AD). Changes in the vascular system of the brain may significantly contribute to the …

Neurovascular dysfunction in dementia–human cellular models and molecular mechanisms

I Parkes, S Chintawar, MZ Cader - Clinical Science, 2018 - portlandpress.com
From the earliest stages of development, when cerebral angiogenesis and neurogenesis
are entwined, to the end of life, the interplay between vascular and neural systems of the …

Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease

R Deane, BV Zlokovic - Current Alzheimer Research, 2007 - ingentaconnect.com
Cerebrovascular dysfunction contributes to the cognitive decline and dementia in
Alzheimer's disease (AD), and may precede cerebral amyloid angiopathy and brain …

[HTML][HTML] Neurovascular dysfunction in vascular dementia, Alzheimer's and atherosclerosis

O Shabir, J Berwick, SE Francis - BMC neuroscience, 2018 - Springer
Efficient blood supply to the brain is of paramount importance to its normal functioning and
improper blood flow can result in potentially devastating neurological consequences …

The early contribution of cerebrovascular factors to the pathogenesis of Alzheimer's disease

PM Pimentel‐Coelho, S Rivest - European Journal of …, 2012 - Wiley Online Library
Alzheimer's disease (AD) and cerebrovascular disorders are the leading causes of dementia
in our ageing population. Given that the progression of neuropathological changes in the …

[HTML][HTML] Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease

AR Nelson, MD Sweeney, AP Sagare… - Biochimica et Biophysica …, 2016 - Elsevier
Vascular insults can initiate a cascade of molecular events leading to neurodegeneration,
cognitive impairment, and dementia. Here, we review the cellular and molecular …

Neurovascular mechanisms of Alzheimer's neurodegeneration

BV Zlokovic - Trends in neurosciences, 2005 - cell.com
In contrast to traditional neuroncentric views of Alzheimer's disease (AD), recent findings
indicate that neurovascular dysfunction contributes to cognitive decline and …

[HTML][HTML] Vascular contributions to cognitive impairment, clinical Alzheimer's disease, and dementia in older persons

A Kapasi, JA Schneider - Biochimica et Biophysica Acta (BBA)-Molecular …, 2016 - Elsevier
There is growing evidence suggesting that vascular pathologies and dysfunction play a
critical role in cognitive impairment, clinical Alzheimer's disease, and dementia. Vascular …

Neurovascular dysfunction and faulty amyloid β-peptide clearance in Alzheimer disease

AP Sagare, RD Bell… - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Neurovascular dysfunction is an integral part of Alzheimer disease (AD). Changes in the
brain vascular system may contribute in a significant way to the onset and progression of …

The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia

C Iadecola - Acta neuropathologica, 2010 - Springer
There is increasing evidence that cerebrovascular dysfunction plays a role not only in
vascular causes of cognitive impairment but also in Alzheimer's disease (AD). Vascular risk …