Hypoxia is an important microenvironmental factor that induces cancer metastasis.
Hypoxia/hypoxia-inducible factor-1α (HIF-1α) regulates many important steps of the …

Metastases formation is a major factor in disease progression and accounts for the majority
of cancer deaths. The molecular mechanisms controlling invasion, dissemination to blood or …

Hypoxia has been recognized as one of the fundamentally important features of solid tumors
and plays a critical role in various cellular and physiologic events, including cell …

Significance: Hypoxia is emerging as a crucial regulator of the tumor microenvironment; it
governs the metastatic potential of multiple primary cancers. It is also potentially involved in …

Hypoxia is a common phenomenon of solid tumors and contributes to aggressive phenotype
and treatment failure. Hypoxia-inducible factor (HIF), a versatile transcription factor that …

Abstract Hypoxia‐inducible factor‐1 (HIF‐1), consisting of oxygen‐sensitive HIF‐1α and
constitutively expressed HIF‐1β subunits, is a master transcriptional activator for cellular …

The hypoxic microenvironment is one of the major features of solid tumors, which regulates
cell malignancy in multiple ways. As a response to hypoxia, a large number of target genes …

Tumor hypoxia has been reported to induce tumor progression in several carcinomas.
Current studies have shown that hypoxia inducible factor-1α (HIF-1α) is stabilized under …

Accumulating evidence has shown that the hypoxic microenvironment, which is critical
during cancer development, plays a key role in regulating breast cancer progression and …

Hypoxia is a common condition found in a wide range of solid tumors and is often
associated with poor prognosis. Hypoxia increases tumor glycolysis, angiogenesis, and …