The aortic wall is composed of highly dynamic cell populations and extracellular matrix. In
response to changes in the biomechanical environment, aortic cells and extracellular matrix …

Rupture of aortic aneurysm and dissection (AAD) remains a leading cause of death.
Progressive smooth muscle cell (SMC) loss is a crucial feature of AAD that contributes to …

Background Aortic aneurysms (AA) are pathological dilations of the aorta, associated with
an overall mortality rate up to 90% in case of rupture. In addition to dilation, the aortic layers …

Aims Acute aortic dissection (AAD) is a life-threatening disease with high morbidity and
mortality. Previous studies have showed that vascular smooth muscle cell (VSMC) …

Vascular remodeling within the aorta results in a loss of structural integrity with consequent
aneurysm formation. This degradation is more common in the abdominal aorta but also …

Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease that affects,
mostly, the elder population, with a high mortality rate (> 80%) upon rupture. It features a …

Abdominal aortic aneurysm (AAA), defined as a focal dilation of the abdominal aorta beyond
50% of its normal diameter, is a common and potentially life-threatening vascular disease …

Abdominal aortic aneurysm (AAA) is a life-threatening disease associated with high
morbidity, and high mortality in the event of aortic rupture. Major advances in open surgical …

Genetic predisposition and risk factors such as hypertension and smoking can instigate the
development of thoracic aortic aneurysm (TAA), which can lead to highly lethal aortic wall …

Abdominal aortic aneurysms (AAAs) are highly lethal cardiovascular diseases without
effective medications. However, the molecular and signaling mechanisms remain unclear. A …