Aortic dissection is an age-dependent life-threatening cardiovascular disease with high
mortality rates. Recent research has shown that inflammation plays an important role in …

Abdominal aortic aneurysms (AAAs) are highly lethal cardiovascular diseases without
effective medications. However, the molecular and signaling mechanisms remain unclear. A …

BACKGROUND: Knowledge in the aetiopathogeny of aortic disease helps to characterise
aortic lesions better and determine the risk of evolution and therapeutic strategies as well …

Aortic aneurysm is an asymptomatic disease with dire outcomes if undiagnosed. Aortic
aneurysm rupture is a significant cause of death worldwide. To date, surgical repair or …

Thoracic aortic aneurysm and dissection (TAAD) affects many patients globally and has high
mortality rates if undetected. Once thought to be solely a degenerative disease that afflicted …

Rationale: Aortic aneurysm and dissection (AAD) are major diseases of the adult aorta
caused by progressive medial degeneration of the aortic wall. Although the overproduction …

Objective—Increasing evidence suggests that contractile dysfunction in smooth muscle cells
(SMCs) plays a critical role in aortic biomechanical dysfunction and aortic aneurysm and …

Thoracic aortic aneurysms involving the root and/or the ascending aorta enlarge over time
until an acute tear in the intimal layer leads to a highly fatal condition, an acute aortic …

Background: Ascending thoracic aortic aneurysm (ATAA) is caused by the progressive
weakening and dilatation of the aortic wall and can lead to aortic dissection, rupture, and …

Objective—Recent studies suggested the occurrence of phenotypic switching of vascular
smooth muscle cells (VSMCs) during the development of aortic aneurysm (AA). However …