Segmental aortic stiffening contributes to experimental abdominal aortic aneurysm development

U Raaz, AM Zöllner, IN Schellinger, R Toh… - Circulation, 2015 - Am Heart Assoc
Background—Stiffening of the aortic wall is a phenomenon consistently observed in age and
in abdominal aortic aneurysm (AAA). However, its role in AAA pathophysiology is largely …

Pathogenic mechanisms and the potential of drug therapies for aortic aneurysm

B Liu, DJ Granville, J Golledge… - American Journal of …, 2020 - journals.physiology.org
Aortic aneurysm is a permanent focal dilation of the aorta. It is usually an asymptomatic
disease but can lead to sudden death due to aortic rupture. Aortic aneurysm-related …

Epigenomics in aortic dissection: From mechanism to therapeutics

Y Tao, G Li, Y Yang, Z Wang, S Wang, X Li, T Yu, X Fu - Life Sciences, 2023 - Elsevier
Aortic dissection (AD) has an unfavorable prognosis. It requires early diagnosis, appropriate
treatment strategies, and suspicion to recognize symptoms; thus, it is commonly described …

Prevention of aortic dissection and aneurysm via an ALDH2-mediated switch in vascular smooth muscle cell phenotype

K Yang, J Ren, X Li, Z Wang, L Xue, S Cui… - European heart …, 2020 - academic.oup.com
Aims Aortic aneurysm/dissection (AAD) is a life-threatening disorder lacking effective
pharmacotherapeutic remedies. Aldehyde dehydrogenase 2 (ALDH2) polymorphism is tied …

Novel mechanisms of abdominal aortic aneurysms

H Lu, DL Rateri, D Bruemmer, LA Cassis… - Current atherosclerosis …, 2012 - Springer
Abdominal aortic aneurysms (AAAs) are a common but asymptomatic disease that has high
susceptibility to rupture. Current therapeutic options are limited to surgical procedures …

Current concepts in the pathogenesis of abdominal aortic aneurysm

G Ailawadi, JL Eliason, GR Upchurch - Journal of vascular surgery, 2003 - jvascsurg.org
Abdominal aortic aneurysms (AAAs) are a significant medical problem with a high mortality.
The primary diagnostic code for AAA accounts for approximately 150,000 inpatient hospital …

Molecular fingerprint for terminal abdominal aortic aneurysm disease

G Gäbel, BH Northoff, I Weinzierl, S Ludwig… - Journal of the …, 2017 - Am Heart Assoc
Background Clinical decision making in abdominal aortic aneurysms (AAA) relies
completely on diameter. At this point, improved decision tools remain an unmet medical …

Insights on the pathogenesis of aneurysm through the study of hereditary aortopathies

TJ Creamer, EE Bramel, EG MacFarlane - Genes, 2021 - mdpi.com
Thoracic aortic aneurysms (TAA) are permanent and localized dilations of the aorta that
predispose patients to a life-threatening risk of aortic dissection or rupture. The identification …

Etiology, pathogenesis and management of thoracic aortic aneurysm

H Ince, CA Nienaber - Nature Clinical Practice Cardiovascular …, 2007 - nature.com
Given the growing proportion of elderly people in Western societies and the increasing
prevalence of chronic hypertension, the management of aneurysmal aortic disease is an …

Possible mechanical roles of glycosaminoglycans in thoracic aortic dissection and associations with dysregulated transforming growth factor-β

JD Humphrey - Journal of vascular research, 2012 - karger.com
Background: Four distinguishing histopathological characteristics of thoracic aortic
aneurysms and dissections (TAADs) are the fragmentation or degradation of elastic fibers …