Lipoprotein (a) and cardiovascular and valvular diseases: a genetic epidemiological perspective

BJ Arsenault, PR Kamstrup - Atherosclerosis, 2022 - Elsevier
Rates of atherosclerotic cardiovascular diseases (CVD) in the Western world have
spectacularly decreased over the past 50 years. However, a substantial proportion of high …

Human genetics and the causal role of lipoprotein (a) for various diseases

F Kronenberg - Cardiovascular drugs and therapy, 2016 - Springer
Abstract Lipoprotein (a)[Lp (a)] is a highly atherogenic lipoprotein that is under strong
genetic control by the LPA gene locus. Genetic variants including a highly polymorphic copy …

Lipoprotein (a) as a potential causal genetic risk factor of cardiovascular disease: a rationale for increased efforts to understand its pathophysiology and develop …

S Tsimikas, JL Hall - Journal of the American College of Cardiology, 2012 - jacc.org
Recent published studies have provided increasing evidence that lipoprotein (a)[Lp (a)] may
be a potential causal, genetic, independent risk factor for cardiovascular disease (CVD). Lp …

Lipoprotein (a): a genetically determined, causal, and prevalent risk factor for atherosclerotic cardiovascular disease: a scientific statement from the American Heart …

G Reyes-Soffer, HN Ginsberg, L Berglund… - … , and vascular biology, 2022 - Am Heart Assoc
High levels of lipoprotein (a)[Lp (a)], an apoB100-containing lipoprotein, are an independent
and causal risk factor for atherosclerotic cardiovascular diseases through mechanisms …

The dedicated “Lp (a) clinic”: a concept whose time has arrived?

S Tsimikas, ESG Stroes - Atherosclerosis, 2020 - Elsevier
The emergence of pathophysiological, epidemiologic, and genetic data strongly supports
the causality for lipoprotein (a)[Lp (a)] in cardiovascular disease (CVD) and calcific aortic …

Lipoprotein (a) in atherosclerotic cardiovascular disease and aortic stenosis: a European Atherosclerosis Society consensus statement

F Kronenberg, S Mora, ESG Stroes… - European heart …, 2022 - academic.oup.com
Abstract This 2022 European Atherosclerosis Society lipoprotein (a)[Lp (a)] consensus
statement updates evidence for the role of Lp (a) in atherosclerotic cardiovascular disease …

Lipoprotein (a) and cardiovascular disease

PR Kamstrup - Clinical chemistry, 2021 - academic.oup.com
Background High lipoprotein (a) concentrations present in 10%–20% of the population have
long been linked to increased risk of ischemic cardiovascular disease. It is unclear whether …

Lipoprotein (a): evidence for role as a causal risk factor in cardiovascular disease and emerging therapies

HS Bhatia, MJ Wilkinson - Journal of clinical medicine, 2022 - mdpi.com
Lipoprotein (a)(Lp (a)) is an established risk factor for multiple cardiovascular diseases.
Several lines of evidence including mechanistic, epidemiologic, and genetic studies support …

Lipoprotein (a) and Cardiovascular Diseases―Revisited―

AY Jang, SH Han, IS Sohn, PC Oh, KK Koh - Circulation Journal, 2020 - jstage.jst.go.jp
Two decades ago, it was recognized that lipoprotein (a)(Lp (a)) concentrations were
elevated in patients with cardiovascular disease (CVD). However, the importance of Lp (a) …

Lipoprotein (a): a genetic marker for cardiovascular disease and target for emerging therapies

A Cesaro, A Schiavo, E Moscarella… - Journal of …, 2021 - journals.lww.com
Abstract Lipoprotein (a)[Lp (a)] is an established cardiovascular risk factor, and growing
evidence indicates its causal association with atherosclerotic disease because of the …