Objectives Dissecting the underlying mechanism of T cells remodeling mediated by
interferon α (IFN-α) is indispensable for achieving an optimum therapeutic response in …

Type I interferon is widely used for antiviral therapy, yet has yielded disappointing results
toward chronic HBV infection. Here we identify that PEG-IFNα-2b therapy toward persistent …

It remains controversial how interferon (IFN) response contributes to hepatitis B virus (HBV)
control and pathogenesis. A previous study identified that hydrodynamic injection (HI) of …

About 0.8 million people die because of hepatitis B virus (HBV) infection each year. In
around 5% of infected adults, the immune system is ineffective in countering HBV infection …

Hepatitis B virus (HBV) infection is a global public health issue. Interferon-α (IFN-α)
treatment has been used to treat hepatitis B for over 20 years, but fewer than 5% of Asians …

Chronic hepatitis B virus (HBV) infection continues to be a global public health burden. B
cells play a pivotal role in mediating HBV clearance and can participate in the development …

Interferon‐α (IFN‐α) is used to treat chronic hepatitis B virus (HBV) infection, but only 20%‐
40% of patients respond well. Clinical observations have suggested that HBV genotype is …

Chronic hepatitis B virus (HBV) infection is one of the main causes of liver diseases, of which
the natural history and clinical outcomes are associated with the role of B cells. As humoral …

Chronic hepatitis B virus (HBV) infection remains a substantial public health burden
worldwide. Alpha-interferon (IFNα) is one of the two currently approved therapies for chronic …

Interferon (IFN)‐α is an indispensable drug for hepatitis B treatment in clinical settings.
However, hepatitis B virus (HBV) can attenuate IFN‐mediated antiviral responses to avoid …