[HTML][HTML] Liver X receptors as regulators of macrophage inflammatory and metabolic pathways

A Noelia, A Castrillo - Biochimica et Biophysica Acta (BBA)-Molecular …, 2011 - Elsevier
The liver X receptors (LXRα and LXRβ) are members of the nuclear receptor family of
transcription factors that play essential roles in the transcriptional control of lipid metabolism …

Liver X receptors as integrators of metabolic and inflammatory signaling

N Zelcer, P Tontonoz - The Journal of clinical investigation, 2006 - Am Soc Clin Investig
The liver X receptors (LXRs) are nuclear receptors that play central roles in the
transcriptional control of lipid metabolism. LXRs function as nuclear cholesterol sensors that …

Liver X receptors, atherosclerosis and inflammation

DR Michael, TG Ashlin, ML Buckley… - Current atherosclerosis …, 2012 - Springer
Liver X receptors (LXRs) belong to the nuclear receptor superfamily of ligand-dependent
transcription factors. LXRs are activated by oxysterols, metabolites of cholesterol, and …

Liver X receptors link lipid metabolism and inflammation

IG Schulman - FEBS letters, 2017 - Wiley Online Library
The response of immune cells to pathogens is often associated with changes in the flux
through basic metabolic pathways. Indeed, in many cases changes in metabolism appear to …

The challenges and promise of targeting the Liver X Receptors for treatment of inflammatory disease

MB Fessler - Pharmacology & therapeutics, 2018 - Elsevier
Abstract The Liver X Receptors (LXRs) are oxysterol-activated transcription factors that
upregulate a suite of genes that together promote coordinated mobilization of excess …

Common and differential transcriptional actions of nuclear receptors liver X receptors α and β in macrophages

A Ramón-Vázquez, JV de la Rosa… - … and cellular biology, 2019 - Taylor & Francis
The liver X receptors α and β (LXR α and LXR β) are oxysterol-activated transcription factors
that coordinately regulate gene expression that is important for cholesterol and fatty acid …

Biological roles of liver X receptors in immune cells

M Pascual-García, AF Valledor - Archivum immunologiae et therapiae …, 2012 - Springer
Liver X receptors (LXRs) are members of the nuclear receptor superfamily that are activated
by specific oxysterols. LXRs heterodimerize with retinoid X receptors to regulate positively …

Liver X receptors in lipid signalling and membrane homeostasis

B Wang, P Tontonoz - Nature Reviews Endocrinology, 2018 - nature.com
Liver X receptors α and β (LXRα and LXRβ) are nuclear receptors with pivotal roles in the
transcriptional control of lipid metabolism. Transcriptional activity of LXRs is induced in …

The roles of liver X receptor α in inflammation and inflammation‐associated diseases

L Zhao, W Lei, C Deng, Z Wu, M Sun… - Journal of cellular …, 2021 - Wiley Online Library
Liver X receptor α (LXRα; also known as NR1H3), an isoform of LXRs, is a member of the
nuclear receptor family of transcription factors and plays essential roles in the transcriptional …

Role of liver X receptors in cholesterol efflux and inflammatory signaling

R Zhu, Z Ou, X Ruan, J Gong - Molecular medicine …, 2012 - spandidos-publications.com
Liver X receptors (LXRs) are nuclear receptors that play a central role in cholesterol
metabolism. When activated, LXRs induce a series of genes that are involved in cholesterol …